- Delafloxacin API
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- $50.00 / 1KG
-
2024-04-26
- CAS:189279-58-1
- Min. Order: 1KG
- Purity: 99.9%
- Supply Ability: 500
- Delafloxacin
-
- $15.00 / 1kg
-
2024-04-26
- CAS:189279-58-1
- Min. Order: 1kg
- Purity: 99.9%
- Supply Ability: 500
- Delafloxacin
-
- $15.00 / 1KG
-
2021-07-13
- CAS:189279-58-1
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
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| | ABT-492 Basic information |
| Product Name: | ABT-492 | | Synonyms: | ABT-492;1-(6-Amino-3,5-difluoro-2-pyridinyl)-8-chloro-6-fluoro-1,4-dihydro-7-(3-hydroxy-1-azetidinyl)-4-oxo-3-quinolinecarboxylic acid;Delafloxacinum;3-Quinolinecarboxylic acid, 1-(6-aMino-3,5-difluoro-2-pyridinyl)-8-chloro-6-fluoro-1,4-dihydro-7-(3-hydroxy-1-azetidinyl)-4-oxo-;WQ3034;ABT-492(WQ-3034);ABT492/ABT-492;1-(6-aMino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-7-(3-hydroxyazetidin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid | | CAS: | 189279-58-1 | | MF: | C18H12ClF3N4O4 | | MW: | 440.76 | | EINECS: | | | Product Categories: | API | | Mol File: | 189279-58-1.mol |  |
| | ABT-492 Chemical Properties |
| Melting point | 238-241℃ | | Boiling point | 698.5±55.0 °C(Predicted) | | density | 1.796 | | storage temp. | 2-8°C | | solubility | DMSO (Slightly), Methanol (Very Slightly, Heated, Sonicated) | | pka | 5.49±0.50(Predicted) | | form | powder | | color | white to beige | | CAS DataBase Reference | 189279-58-1 |
| | ABT-492 Usage And Synthesis |
| Uses | Delafloxacin is a potent agent and broad-spectrum anionic fluoroquinolone against Streptococcus pneumoniae and diverse group of pathogens. | | Biochem/physiol Actions | Delafloxacin is a fluoroquinolone antibiotic active against both Gram-negative and Gram-positive bacteria such as MRSA. Delafloxacin targets both DNA gyrase and topoisomerase IV, inhibiting DNA synthesis. Unlike most fluoroquinolones, delafloxacin is weakly acidic, which increases its potency in an acidic environments such as those existing in inflammatory cells and in skin and soft tissue infections. Delafloxacin shows good activity against most fluoroquinolone-resistant strains. |
| | ABT-492 Preparation Products And Raw materials |
| Raw materials | Benzenepropanoic acid, α-(ethoxymethylene)-2,4,5-trifluoro-β-oxo-, ethyl ester-->3-Quinolinecarboxylic acid, 1-(6-amino-3,5-difluoro-2-pyridinyl)-8-chloro-6,7-difluoro-1,4-dihydro-4-oxo-, ethyl ester-->1-(6-Amino-3,5-difluoro-2-pyridinyl)-8-chloro-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid-->3-Quinolinecarboxylic acid, 1-(6-amino-3,5-difluoro-2-pyridinyl)-8-chloro-6-fluoro-1,4-dihydro-7-[3-(2-methyl-1-oxopropoxy)-1-azetidinyl]-4-oxo-, ethyl ester-->Ethyl 2,4,5-trifluorobenzoylacetate-->2,4,5-Trifluorobenzoic acid-->3-quinolinecarboxylic acid, 1-(6-amino-3,5-difluoro-2-pyridinyl)-8-chloro-6,7-difluoro-1,4-dihydro-4-oxo-, ethyl ester-->2,4,5-Trifluorobenzoyl chloride-->ETHYL 3-(3-CHLORO-2,4,5-TRIFLUOROPHENYL)-3-OXOPROPANOATE-->3-Hydroxyazetidine hydrochloride-->1-Methylpyrrolidine | | Preparation Products | ABT-492 MegluMine |
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