倒千里光碱
中文名称 | 倒千里光碱 |
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中文同义词 | 探讨倒千里光碱;倒千里光碱(>90%,BC);倒千里光碱;逆丙氨酸 |
英文名称 | RETRORSINE |
英文同义词 | BETA-LONGILOBINE;12,18-DIHYDROXYSENECIONAN-11,16-DIONE;RETRORSINE;16-dione,12,18-dihydroxy-senecionan-1;5,6,9,11,13,14,14a,14b-decahydro-6-hydroxy-6-hydroxymethyl-5-3-ethylidene-4;cis-retronecicacidesterofretronecine;methyl(1,6)dioxacyclododeca(2,3,4-gh)pyrrolizidine-2,7-dione;trans-15-ethylidene-12beta-hydroxy-12alpha-hydroxymethyl-13beta-methylsenec-1- |
CAS号 | 480-54-6 |
分子式 | C18H25NO6 |
分子量 | 351.39 |
EINECS号 | 610-403-9 |
相关类别 | 生化试剂;对照品;中药对照品 |
Mol文件 | 480-54-6.mol |
结构式 |
倒千里光碱 性质
熔点 | 208-211 °C (lit.) |
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比旋光度 | D18 -17.6° (c = 1.99 in ethanol) |
沸点 | 485.2°C (rough estimate) |
密度 | 1.32±0.1 g/cm3 (20 ºC 760 Torr) |
折射率 | 1.5100 (estimate) |
储存条件 | 2-8°C |
形态 | 固体 |
酸度系数(pKa) | 12.00±0.40(Predicted) |
颜色 | 白色至米白色 |
Merck | 13,8253 |
InChIKey | BCJMNZRQJAVDLD-VMOBWIEOSA-N |
CAS 数据库 | 480-54-6 |
(IARC)致癌物分类 | 3 (Vol. 10, Sup 7) 1987 |
EPA化学物质信息 | Retrorsine (480-54-6) |
Retrorsine 是一种天然存在的有毒吡咯利西啶生物碱。Retrorsine 可以与 DNA 结合,抑制肝细胞的增殖能力。Retrorsine 可用于肝细胞损伤的研究。
Retrorsine (60-240 μM; 24 hours) significantly reduces HSEC-CYP3A4 cells viability and GSH levels, and increases formation of pyrrole-protein adducts.
Cell Viability Assay
Cell Line: | HSEC-CYP3A4 cells |
Concentration: | 60 μM, 120 μM , 240 μM |
Incubation Time: | 24 hours |
Result: | Significantly decreased cell viability. |
Retrorsine (30 mg/kg; i.p.; twice) impairs liver regeneration in the PBL model not only by an S or G2/M phase block, but also by a block located before the G1/S transition of the cell cycle.
Animal Model: | Male Wistar rats (180±20 g), portal branch ligation (PBL) model |
Dosage: | 30 mg/kg |
Administration: | Intraperitoneal injection, twice, separated by 2-week interval |
Result: | Strongly impaired the liver weight gain, protein and DNA synthesis as well as induction of cell cycle related proteins in the regenerating lobes after PBL. |
安全信息
危险品标志 | T |
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危险类别码 | 25 |
安全说明 | 22-36/37/39-45 |
危险品运输编号 | 1544 |
WGK Germany | 3 |
RTECS号 | VH7525000 |
危险等级 | 6.1(a) |
包装类别 | II |
毒害物质数据 | 480-54-6(Hazardous Substances Data) |
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-N6638 | Retrorsine | 1 mg | 761元 | |
2024/08/19 | HY-N6638 | 倒千里光碱 Retrorsine | 480-54-6 | 5mg | 1600元 |