D-ERYTHRO-SPHINGOSINE

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Company Name: Hebei Mojin Biotechnology Co., Ltd
Tel: +86-13288715578 +86-13231137666
Email: sales@hbmojin.com
Products Intro: Product Name:D-ERYTHRO-SPHINGOSINE
CAS:123-78-4
Purity:99% Package:25KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: +86-0371-55170693 +86-19937530512
Email: info@tianfuchem.com
Products Intro: Product Name:D-ERYTHRO-SPHINGOSINE
CAS:123-78-4
Purity:99% Package:25KG;5KG;1KG
Company Name: Nanjing ChemLin Chemical Industry Co., Ltd.
Tel: 025-83697070
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Products Intro: CAS:123-78-4
Purity:98% Package:g-Kg
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
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Products Intro: Product Name:D-erythro-sphingosine
CAS:123-78-4
Purity:98% HPLC Package:5G;10G;25G;50G;100G;250G;1KG
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Tel: +86-0371-86658258
Email: sales@coreychem.com
Products Intro: Product Name:D-ERYTHRO-SPHINGOSINE
CAS:123-78-4
Purity:99% Package:1kg;1USD

D-ERYTHRO-SPHINGOSINE manufacturers

  • D-ERYTHRO-SPHINGOSINE
  • D-ERYTHRO-SPHINGOSINE pictures
  • $0.00 / 25KG
  • 2023-08-22
  • CAS:123-78-4
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 50000KG/month
  • D-erythro-Sphingosine
  • D-erythro-Sphingosine pictures
  • $0.00 / 200Kg
  • 2023-02-11
  • CAS:123-78-4
  • Min. Order: 1000Kg
  • Purity: 98.0%
  • Supply Ability: 1kg/month
  • D-ERYTHRO-SPHINGOSINE
  • D-ERYTHRO-SPHINGOSINE pictures
  • $1.00 / 1PCS
  • 2021-07-29
  • CAS:123-78-4
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 10 mt
D-ERYTHRO-SPHINGOSINE Basic information
Product Name:D-ERYTHRO-SPHINGOSINE
Synonyms:SPHINGOSINE, C18 CHAIN;TRANS D-THREO-SPHINGOSINE;TRANS D-ERYTHRO-SPHINGOSINE;TRANS-D-ERYTHRO-2-AMINO-4-OCTADECENE-1,3-DIOL;BRAIN SPHINGOSINE;BRAIN, BOVINE;EGG SPHINGOSINE;D-SPHINGOSINE (BOVINE)
CAS:123-78-4
MF:C18H37NO2
MW:299.49
EINECS:204-651-3
Product Categories:Amines;Protein Kinase;Mixed Fatty Acids;Fatty Acid Derivatives & Lipids;Glycerols;Inhibitors;Protein Kinase Inhibitors and Activators;Elisa Kit-plant ELISA Kit
Mol File:123-78-4.mol
D-ERYTHRO-SPHINGOSINE Structure
D-ERYTHRO-SPHINGOSINE Chemical Properties
Melting point 74.2-78.1 °C
Boiling point 440.8°C (rough estimate)
density 0.9758 (rough estimate)
refractive index 1.5000 (estimate)
storage temp. -20°C
solubility chloroform: 20 mg/mL, clear, colorless to very faintly yellow
pka11.80±0.45(Predicted)
form Powder or Waxy Solid
color White to cream
Merck 14,8747
BRN 1727294
Stability:Stable. Incompatible with strong acids, strong bases, strong oxidizing agents.
InChIKeyWWUZIQQURGPMPG-KRWOKUGFSA-N
CAS DataBase Reference123-78-4
Safety Information
Safety Statements 22-24/25
WGK Germany 3
1-8-10
HS Code 29221985
MSDS Information
ProviderLanguage
ACROS English
SigmaAldrich English
D-ERYTHRO-SPHINGOSINE Usage And Synthesis
DescriptionSphingosine (123-78-4) is an inhibitor of protein kinase C (IC50 = 1-3 μM).1 It is abundant in cell membranes and is an important mediator in various biochemical pathways.2-4
Chemical PropertiesWhite Crystalline Solid
UsesSphingosine (d18:1) has been used:
  • for sphingosine inhalations studies in mice to evaluate its therapeutic potential in respiratory epithelial cells
  • to investigate its effect on Pseudomonas aeruginosa strains
  • as a standard in liquid chromatography tandem mass spectrophotometry for the quantification of epidermal ceramides

UsesSelective inhibitor of protein kinase C activity and phorbol dibutyrate binding in vitro in human platelets; does not inhibit protein kinase A or myosin light chain kinase; inhibits calmodulin-dependent enzymes; natural isomer of sphingosine
UsesD-erythro-Sphingosine is used to inhibits protein kinase C and calmodulin-dependent enzymes, induces apoptosis. And also used to constituent of cell membranes.
Definitioncerebroside: Any one of a class ofglycolipids in which a single sugarunit is bound to a sphingolipid. The most commoncerebrosides are galactocerebrosides,containing the sugar group galactose;they are found in the plasma membranesof neural tissue and are abundantin the myelin sheaths ofneurones.
General DescriptionSphingosine (d18:1) is a spingoid base present in plant and animals. It has 2-amino-1,3-diol functionality and its extraction from animal tissue is laborious. Sphingosine (d18:1) synthesis is performed by chirospecific method using D-galactose.
Biological ActivityInhibitor of protein kinase C and calmodulin-dependent enzymes, but may stimulate mast cells by activation of protein kinase C.
Biochem/physiol ActionsA constituent of cell membranes. Precursor of ceramide. Selective inhibitor of protein kinase C, but does not inhibit protein kinase?A or myosin light chain kinase. Inhibitor of calmodulin-dependent enzymes.
Purification MethodsD-Sphingosine is purified by recrystallisation from EtOAc, Et2O or pet ether (60-80o). It is insoluble in H2O but is soluble in Me2CO, EtOH and MeOH. It has IR bands at 1590 and 875 cm-1, and is characterised as the tribenzoate m 122-123o (from 95% EtOH). [Tipton Biochemical Preparations 9 127 1962.]
References1) Merrill et al., (1989) Structural requirements for long-chain (sphingoid) base inhibition of protein kinase C in vitro and for the cellular effects of these compounds; Biochemistry, 28 3138 2) Ohanian and Ohanian (2001) Sphingolipids in mammalian cell signaling; Cell. Mol. Life Science, 58 2053 3) Ruvolo (2003) Intracellular signal transduction pathways activated by ceramide and its metabolites; Pharm. Res., 47 383 4) Olivier (2002) Sphingosine in apoptosis signaling; Biochim. Biophys. Acta, 1585 153
D-ERYTHRO-SPHINGOSINE Preparation Products And Raw materials
Tag:D-ERYTHRO-SPHINGOSINE(123-78-4) Related Product Information
D-ERYTHRO-SPHINGOSINE, N-OCTANOYL- LIGNOCERIC CERAMIDE,C14-D-ERYTHRO-SPHINGOSINE D-ERYTHRO-SPHINGOSINE SPHINGOMYELIN (BOVINE), [CHOLINE METHYL-14C] C18-CEREBROSIDE C12 NBD-D-ERYTHRO-DIHYDROSPHINGOSINE N-Teracosanoyl-D-Spingosine C6 NBD-D-ERYTHRO-DIHYDROSPHINGOSINE C20-D-ERYTHRO-SPHINGOSINE D-ERYTHRO-SPHINGOSINE, N-PALMITOYL N-Pentadecanoyl-D-Sphingosine? N-Pentadecanoyl-psychosine? D-ERYTHRO-SPHINGOSINE, N-STEAROYLDIHYDRO,D-ERYTHRO-SPHINGOSINE, N-STEAROYL- C12 NBD-L-THREO-DIHYDROSPHINGOSINE N-Nervonoyl-D-Spingosine 6-HEXANOYL-D-ERYTHRO-SPHINGOSINE,D-ERYTHRO-SPHINGOSINE, N-HEXANOYL- D-GALACTOSYL-B1-1'-D-ERYTHRO-SPHINGOSINE LYSO-CERAMIDE TRIHEXOSIDE