伊曲茶碱杂质
中文名称 | 伊曲茶碱杂质 |
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中文同义词 | 伊曲茶碱杂质14;4-去甲基伊曲茶碱;4-去甲基异氟烷;伊曲茶碱杂质869 |
英文名称 | 4-DesMethyl Istradefylline |
英文同义词 | (E)-1,3-diethyl-8-(4-hydroxy-3-methoxystyryl)-7-methyl-1H-purine-2,6(3H,7H)-dione;4-DesMethyl Istradefylline impurity;Istradefylline Impurity 14;1H-Purine-2,6-dione, 1,3-diethyl-3,7-dihydro-8-[2-(4-hydroxy-3-methoxyphenyl)ethenyl]-7-methyl-, (E)- (9CI);Istradefylline 4-O-Desmethyl Impurity;Istradefylline M1 metabolite;Itraphylline impurities869;Itraphylline impurities6 |
CAS号 | 160434-48-0 |
分子式 | C19H22N4O4 |
分子量 | 370.4 |
EINECS号 | |
相关类别 | 杂质对照品;Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals |
Mol文件 | 160434-48-0.mol |
结构式 |
伊曲茶碱杂质 性质
沸点 | 604.8±65.0 °C(Predicted) |
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密度 | 1.30±0.1 g/cm3(Predicted) |
酸度系数(pKa) | 9.88±0.31(Predicted) |
4-Desmethyl Istradefylline 是 Istradefylline 的代谢物。Istradefylline 是一种有效的,选择性的,可口服的 adenosine A2A receptor 拮抗剂,在帕金森疾病模型试验中,Ki 值为 2.2 nM。
用途
4-Desmethyl Istradefylline is an impurity of Istradefylline (I927000), a selective A(2A) antagonist used in the treatment of Parkinson鈥檚 disease. 4-Desmethyl Istradefylline have also been shown to exh
ibit inhibitory potency towards adenosine A2A receptors and is classified as its an adenosine A2A receptor antagonist.