| Company Name: |
Borenpharm Co., Ltd
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| Tel: |
027-65563561 |
| Email: |
sales@borenpharm.com |
| Products Intro: |
Product Name:Propargyl-peg3-1-o-(b-cyanoethyl-n,n-diisopropyl)phosphoramidite
CAS:1391728-01-0
Purity:95% HPLC Package:1g; 5g Remarks:1.5g
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| Company Name: |
Jinan elephant international trading co., LTD
|
| Tel: |
|
| Email: |
13006575422@163.com |
| Products Intro: |
Product Name:Propargyl-PEG3-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite
CAS:1391728-01-0
Purity:99% HPLC Package:5KG;1KG
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| Company Name: |
Shaanxi Xinyan Bomei Biotechnology Co., Ltd.
|
| Tel: |
029-86217788 13892832556 |
| Email: |
2440688701@qq.com |
| Products Intro: |
Product Name:Propargyl-PEG3-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite
CAS:1391728-01-0
Purity:95% HPLC Package:1g;5g;10g;25g;100g;1kg
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| | Propargyl-PEG3-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite Basic information |
| | Propargyl-PEG3-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite Chemical Properties |
| Boiling point | 387.2±37.0 °C(Predicted) | | pka | 3.53±0.70(Predicted) |
| | Propargyl-PEG3-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite Usage And Synthesis |
| Biological Activity | Propargyl-PEG3-1-o-b-cyanoethyl-NN-diisopropylphosphoramidite is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | | References | [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
| | Propargyl-PEG3-1-O-(b-cyanoethyl-N,N-diisopropyl)phosphoramidite Preparation Products And Raw materials |
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