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| | Ibrutinib-biotin Basic information |
| Product Name: | Ibrutinib-biotin | | Synonyms: | Ibrutinib-biotin;Ibrutinib-biotin-1;Reaxys ID: 26833452;Pentanediamide, N1-[4-[[4-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinyl]-4-oxo-2-buten-1-yl]methylamino]butyl]-N5-[19-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-15-oxo-4,7,10-trioxa-14-azanonadec-1-yl]-;N1-(4-(((E)-4-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-4-oxobut-2-en-1-yl)(methyl)amino)butyl)-N5-(15-oxo-19-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-4,7,10-trioxa-14-azanonadecyl)glutaramide | | CAS: | 1599432-18-4 | | MF: | C56H80N12O9S | | MW: | 1097.3744 | | EINECS: | | | Product Categories: | | | Mol File: | 1599432-18-4.mol |  |
| | Ibrutinib-biotin Chemical Properties |
| Boiling point | 1288.9±65.0 °C(Predicted) | | density | 1.33±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: 50 mg/mL (45.56 mM) | | pka | 13.90±0.40(Predicted) |
| | Ibrutinib-biotin Usage And Synthesis |
| Biological Activity | Ibrutinib-biotin is a probe composed of Ibrutinib linked to biotin through a long chain linker. For details, please refer to Compound 1-5 in WO2014059368A1. It inhibits BTK with an IC50 value of 0.755-1.02 nM. | | in vitro | Ibrutinib-biotin (Compound 1-5) is a probe that consists of Ibrutinib linked to biotin via a long chain linker. Ibrutinib is a TEC family kinase inhibitor. The TEC kinase family is composed of five members, TEC , BTK (Bruton's Tyrosine Kinase), ITK (interleukin-2-inducible T-cell kinase)/EMT/TSK, BMX and TXK/RLK. The TEC family kinases participate in phosphotyrosine-mediated and phospholipid-mediated signaling systems. Many TEC family proteins are abundantly expressed in hematopoietic tissues, and play important roles in the growth and differentiation processes of blood cells. | | target | IC50: 0.755-1.02 nM (BTK), 1.71-2.29 nM (TEC), 3.66-4.27 nM (BLK), 4.42-5.57 nM (BMX), 5.99-6.92 nM (LCK), 33.8- 36.3 nM (Src), 0.187-0.198 μM (ITK), 5.34-4.87 μM (JAK3) |
| | Ibrutinib-biotin Preparation Products And Raw materials |
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