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2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)-

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2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:AS-041164
CAS:6318-41-8
Package:1 mL * 10mM (in DMSO)；10 mg；100 mg；200 mg；25 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: InvivoChem
Tel: +1-708-310-1919 +1-13798911105
Email: sales@invivochem.cn
Products Intro: Product Name:AS-041164
CAS:6318-41-8
Purity:98% Package:10mg Remarks:V2337
Company Name: Shanghai EFE Biological Technology Co., Ltd.  
Tel: 021-65675885 18964387627
Email: info@efebio.com
Products Intro: Product Name:AS-041164
CAS:6318-41-8
Purity:98% (TLC) Package:5mg;10mg;25mg
Company Name: Tianjin Kailiqi Biotechnology Co., Ltd.  
Tel: 15076683720
Email: klq@cw-bio.com
Products Intro: Product Name:AS-041164
CAS:6318-41-8
Purity:>98 Package:1g,5g,10g,25g根据客户需要分装 Remarks:2g
Company Name: Shanghai Chaolan Chemical Technology Center  
Tel: QQ:65489617 15618227136
Email: info@SuperLan-chem.com
Products Intro: Product Name:AS-041164
CAS:6318-41-8
Purity:98% HPLC Package:5MG;10MG;50MG;100MG,1G,5G,500G
2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- Basic information
Product Name:2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)-
Synonyms:2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)-;PI 3-Kγ Inhibitor VII - CAS 6318-41-8 - Calbiochem;Inhibitor,PI3Kγ,inhibit,Phosphoinositide 3-kinase,AS 041164,AS-041164,anti-inflammatory,neutrophil,recruitment,AS041164,RANTES,PI3K;5-(Benzo[d][1,3]dioxol-5-ylmethylene)thiazolidine-2,4-dione
CAS:6318-41-8
MF:C11H7NO4S
MW:249.24
EINECS:
Product Categories:
Mol File:6318-41-8.mol
2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- Structure
2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- Chemical Properties
density 1.595±0.06 g/cm3(Predicted)
storage temp. +2C to +8C
solubility Soluble in DMSO (up to 25 mg/ml).
form Yellow solid
pka7.13±0.20(Predicted)
color Yellow
Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Safety Information
MSDS Information
2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- Usage And Synthesis
DescriptionThe phosphatidylinositol 3-kinases (PI3Ks) are lipid and protein kinases involved in diverse biological processes, including cell growth, migration, and metabolism. AS-041164 is a potent inhibitor of PI3K with selectivity for the class IB isoform PI3Kγ (IC50 = 70 nM), compared to PI3Kα (IC50 = 240 nM), PI3Kβ (IC50 = 1.45 μM), and PI3Kδ (IC50 =1.70 μM). When tested at 1.0 μM, it shows little or no activity against 38 other common kinases. When given orally to mice, AS-041164 shows a pharmacokinetic profile that is similar to the general PI3K inhibitor LY294002 but is three times more potent (ED50 = 27.4 mg/kg for AS-041164 versus 81.6 mg/kg for LY294002) in blocking neutrophil recruitment induced by RANTES.
References1) Ferrandi et al. (2007) Phosphoinositide 3-kinase gamma inhibition plays a crucial role in early steps of inflammation by blocking neutrophil recruitment: J. Pharmacol. Exp. Ther. 322 923
2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)- Preparation Products And Raw materials
Tag:2,4-Thiazolidinedione,5-(1,3-benzodioxol-5-ylmethylene)-(6318-41-8) Related Product Information
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