| Company Name: |
Shanghai Huzhen Industrial Co., LTD
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| Tel: |
021-60345367 13916550749 |
| Email: |
sales@shzbio.com |
| Products Intro: |
Product Name:PAI1
Purity:> 99% Package:50ul/RMB 1098;100ul/RMB 1880;200ul/RMB 2900 Remarks:Clade E; Endothelial plasminogen activator inhibitor; Nexin; PAI 1; PAI; PAI-1; PAI1_HUMAN; PLANH1; Plasminogen activator inhibitor 1; Plasminogen activator inhibitor type 1; Serin
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| Company Name: |
United States Biological
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| Tel: |
1-800-520-3011 |
| Email: |
sales@advtechind.com |
| Products Intro: |
Product Name:Plasminogen Activator Inhibitor Type 1, Mouse Assay Kit, BioAssay™ (PAI-1)
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| Product Name: | PAI-1 | | Synonyms: | ARMAPE;MOUSE PAI-1;MOUSE PLASMINOGEN ACTIVATOR INHIBITOR-1;PAI-1;PAI-1, HUMAN;PAI-1, MOUSE;PAI-1, MUTANT, MOUSE;PAI-1, RAT | | CAS: | | | MF: | C27H47N9O9S | | MW: | 673.78 | | EINECS: | | | Product Categories: | enzyme | | Mol File: | Mol File |  |
| | PAI-1 Chemical Properties |
| | PAI-1 Usage And Synthesis |
| Enzyme inhibitor | This 402-residue serine protease inhibitor, or serpin (MW = 45074 g/mol; Abbreviation: PAI-1) binds to and inhibits plasminogen activators-tissuetype plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA). This inhibition reduces plasmin production and suppresses dissolution of fibrin clots. Elevated PAI-1 levels correlate with an increased cardiovascular disease risk, a behavior that has also been linked to obesity and metabolic syndrome. Pharmacological suppression of PAI-1 is a likely way to prevent or treat vascular disease. Reduced PAI-1 levels may result in increased fibrinolysis and an associated bleeding diathesis. PAI-1 was initially identified in the 1980s, and the first reported case of PAI-1 deficiency appeared in 1989. Unambiguous proof that PAI-1 deficiency as a cause of a bleeding disorder has been rare, but use of selective PAI inhibitors (See PAI-749) may clarify this point. Because of lack of standardized commercially available PAI-1 activity assay sensitive in the lowest range, the true prevalence of this rare condition has yet to be established. |
| | PAI-1 Preparation Products And Raw materials |
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