香橙素
中文名称 | 香橙素 |
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中文同义词 | 二氢莰非醇;香橙素,香树素;香橙素(标准品);二氢山奈酚;二氢化萜醇;香橙素(二氢山奈酚 );二氢山柰酚;(2R,3R)-3,5,7-三羟基-2-(4-羟基苯基)四氢苯并吡喃-4-酮 |
英文名称 | DIHYDROKAEMPFEROL |
英文同义词 | 3,5,7,4'-TETRAHYDROXYFLAVANONE;DIHYDROKAEMPFEROL;(2R)-2,3-Dihydro-3β,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one;(2R,3R)-2,3-Dihydro-2-(4-hydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one;DIHYDROKAEMPFEROL-CMPD;(2R,3R)-2,3- Dihydro-3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one;AroMadendrin (DihydrokaeMpferol);(2R,3R)-3,5,7-trihydroxy-2-(4-hydroxyphenyl)-2,3-dihydro-4H-chroMen-4-one |
CAS号 | 480-20-6 |
分子式 | C15H12O6 |
分子量 | 288.25 |
EINECS号 | 687-473-2 |
相关类别 | 标准品;植物提取物;分析试剂标准品;对照品;标准品 -对照药材;Flavanones;黄酮;对照品 |
Mol文件 | 480-20-6.mol |
结构式 |
香橙素 性质
熔点 | 237~241℃ |
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沸点 | 139-140 °C |
密度 | 1.599±0.06 g/cm3(Predicted) |
储存条件 | Sealed in dry,2-8°C |
溶解度 | DMSO:2.88(最大浓度 mg/mL);10.0(最大浓度 mM) |
酸度系数(pKa) | 7.42±0.60(Predicted) |
形态 | 固体 |
颜色 | 白色至米白色 |
InChIKey | PADQINQHPQKXNL-LSDHHAIUSA-N |
LogP | 2.860 (est) |
EPA化学物质信息 | 4H-1-Benzopyran-4-one, 2,3-dihydro-3,5,7-trihydroxy-2-(4-hydroxyphenyl)-, (2R,3R)- (480-20-6) |
Apoptosis; Bcl-2; Bcl-xL
Dihydrokaempferol (0.3-300 μM; 48 hours) has no significant effect on normal synoviocytes, but dependently decreases the viability of RA-FLSs. Dihydrokaempferol (3-30 μM; 48 hours) increases the percentage of apoptotic cells (including early and late apoptotic cells; ~3.8% and ~9.6%, respectively). Dihydrokaempferol (3-30 μM; 48 hours) promotes Bax and Bad expression and inhibits Bcl-2 and Bcl-xL expression, increases the cleaved fragments of caspase-3, caspase-9 and cleaved PARP.
Cell Proliferation Assay
Cell Line: | Normal synoviocyte cells; RA-FLS cells |
Concentration: | 0.3 μM, 3 μM, 30 μM, 300 μM |
Incubation Time: | 48 hours |
Result: | Decreased the proliferation of RA-FLSs. |
Apoptosis Analysis
Cell Line: | RA-FLS cells |
Concentration: | 3 μM, 30 μM |
Incubation Time: | 48 hours |
Result: | Induced apoptosis in RA-FLSs. |
Western Blot Analysis
Cell Line: | RA-FLS cells |
Concentration: | 3 μM, 30 μM |
Incubation Time: | 48 hours |
Result: | Promoted Bax and Bad expression, increased the cleaved fragments of caspase-3, caspase-9 and cleaved PARP and inhibited Bcl-2 and Bcl-xL expression. |
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-N2897 | Dihydrokaempferol | 1 mg | 571元 | |
2024/08/19 | HY-N2897 | 香橙素 Dihydrokaempferol | 480-20-6 | 5mg | 1500元 |