远志酸
| 中文名称 | 远志酸 |
|---|---|
| 中文同义词 | 毛果一枝黄花皂苷元G;远志酸(标准品);远志酸;远志酸, 来源于远志;远志酸,毛果一枝黄花皂苷元G |
| 英文名称 | Polygalacic acid |
| 英文同义词 | Polygalacic acid;Polygalacic;(2b,3b,4a,16a)-2,3,16,23-Tetrahydroxyolean-12-en-28-oic acid;Olean-12-en-28-oicacid, 2,3,16,23-tetrahydroxy-, (2β,3β,4,16)-;Virgaureagenin G;(4R)-2β,3β,16α,23-Tetrahydroxyolean-12-en-28-oic acid;Polygalacic acid or (2b,3b,4a,16a)-2,3,16,23-Tetrahydroxyolean-12-en-28-oic acid;Polygalacic acid (2b,3b,4a,16a)-2,3,16,23-Tetrahydroxyolean-12-en-28-oic acid |
| CAS号 | 22338-71-2 |
| 分子式 | C30H48O6 |
| 分子量 | 504.7 |
| EINECS号 | |
| 相关类别 | 中药对照品;标准品;分析标准品;植物提取物;植提标准品;中药标准品;对照品;标准品，对照品;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;标准品-对照品;标准品-中药标准品 |
| Mol文件 | 22338-71-2.mol |
| 结构式 |  |
远志酸 性质
| 熔点 | 300-305 °C (sublm) |
|---|---|
| 沸点 | 638.1±55.0 °C(Predicted) |
| 密度 | 1.23±0.1 g/cm3(Predicted) |
| 储存条件 | 4°C, protect from light |
| 溶解度 | 溶于氯仿、二氯甲烷、乙酸乙酯、DMSO、丙酮等。 |
| 形态 | 粉末 |
| 酸度系数(pKa) | 4.41±0.70(Predicted) |
Polygalacic acid 是从远志属植物（Polygala paenea L.）分离出的三萜类四羟酸。Polygalacic acid (0-100μM; 24h) 可以显著降低 MMP-3、MMP-9、MMP-13 和 COX-2 的mRNA表达，这些因子的表达由IL-1β诱导可显著增加，并呈现出剂量依赖性。
Polygalacic acid (0-100 μM; 24 hours) significantly decreases the mRNAexpressions of MMP-3, MMP-9, MMP-13, and COX-2, which are significantly increased by IL-1β, in a dose-dependent manner. Polygalacic acid (0-100 μM; 6 hours) decreases the expression of phosphor-p38, phosphor-Erk, and phosphor-Jnk induced by IL-1β, phosphor-p65 is not reduced by polygalacic acid.
RT-PCR
| Cell Line: | Chondrocyte cells |
| Concentration: | 50 μM; 100 μM |
| Incubation Time: | 24 hours |
| Result: | Suppressed IL-1β-induced COX-2, MMP3, MMP9, and MMP13 mRNA expression. |
Western Blot Analysis
| Cell Line: | Chondrocyte cells |
| Concentration: | 50 μM; 100 μM |
| Incubation Time: | 6 hours |
| Result: | Inhibited the IL-1β-induced activation of the MAPK pathway in chondrocytes. |
用途
安神，祛痰，消肿等，临床多用于治疗支气管炎和引产，催产等。安全信息
| 海关编码 | 29163990 |
|---|
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/01/25 | HY-N0801 | 远志酸 Polygalacic acid | 22338-71-2 | 1mg | 1100元 |
| 2024/01/25 | HY-N0801 | 远志酸 Polygalacic acid | 22338-71-2 | 5mg | 3200元 |