乌替普利
| 中文名称 | 乌替普利 |
|---|---|
| 中文同义词 | 乌替普利;化合物 T13274 |
| 英文名称 | Utibapril |
| 英文同义词 | (2S)-5-tert-Butyl-3-[(2S)-2-[[(1S)-1-ethoxycarbonyl-3-phenylpropyl]amino]propanoyl]-2,3-dihydro-1,3,4-thiadiazole-2β-carboxylic acid;FPL-63547;Utibapril;1,3,4-Thiadiazole-2-carboxylic acid, 5-(1,1-dimethylethyl)-3-[(2S)-2-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]-1-oxopropyl]-2,3-dihydro-, (2S)- |
| CAS号 | 109683-61-6 |
| 分子式 | C22H31N3O5S |
| 分子量 | 449.569 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 109683-61-6.mol |
| 结构式 |  |
乌替普利 性质
| 储存条件 | Store at -20°C |
|---|---|
| 溶解度 | 溶于二甲基亚砜 |
Utibapril 是一种 angiotensin-converting enzyme (ACE) 抑制剂，具有抗高血压的功效。
Utibapril significantly inhibits plasma, renal, and vascular ACE but not ventricular ACE activity. Utibapril (2 μg/kg/day) significantly inhibits vascular ACE activity, and Utibapril (250 μg/kg/day) results in a significant inhibition of plasma ACE. Furthermore, angiotensin I-induced decreases in coronary flow in the isolated heart are significantly inhibited after treatment with the higher doses of utibapril. FPL 63547 is rapidly and extensively excreted as the diacid in the bile but appeared in the urine in negligible amounts.