羟保松
中文名称 | 羟保松 |
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中文同义词 | 羟保松;羟布宗;羟基保泰松;羟基保泰松,坦特利尔,羟保松;羟基保泰松溶液,100PPM;化合物 T16419 |
英文名称 | OXYPHENYL BUTAZONE |
英文同义词 | butanora;Butanova;Butapirone;Butazonic;Californit;Crovaril;Deflogin;Etrozolidina |
CAS号 | 129-20-4 |
分子式 | C19H20N2O3 |
分子量 | 324.37 |
EINECS号 | 204-936-2 |
相关类别 | 抗炎镇痛药物;Active Pharmaceutical Ingredients;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals |
Mol文件 | 129-20-4.mol |
结构式 |
羟保松 性质
熔点 | 109-111°C |
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沸点 | 462.71°C (rough estimate) |
密度 | 1.2118 (rough estimate) |
折射率 | 1.6140 (estimate) |
储存条件 | -20°C |
溶解度 | DMSO:可溶10mg/mL,澄清 |
酸度系数(pKa) | pKa 4.7/10.0±0.2(H2O,t =25,Iundefined) (Uncertain) |
形态 | 粉末 |
颜色 | 白色至棕色 |
水溶解性 | 20mg/L(room temperature) |
稳定性 | 吸湿性 |
CAS 数据库 | 129-20-4(CAS DataBase Reference) |
(IARC)致癌物分类 | 3 (Vol. 13, Sup 7) 1987 |
EPA化学物质信息 | 3,5-Pyrazolidinedione, 4-butyl-1-(4-hydroxyphenyl)-2-phenyl- (129-20-4) |
COX
Oxyphenbutazone enhances the anticancer efficiency of methotrexate (MTX) in Hep3B cells.
Oxyphenbutazone (2.5 -7.5 µM; 48 hours) co-treatment with (MTX, 0.25-1.0 µM) shows potential cytotoxicity against Hep3B cells.
Oxyphenbutazone exhibits reparative effects in the hepatocytes.
Cell Cytotoxicity Assay
Cell Line: | Hep3B cells |
Concentration: | 2.5 µM, 5 µM, 7.5 µM |
Incubation Time: | 48 hours |
Result: | Enhanced the cytotoxicity of MTX. |
Oxyphenbutazone (70 mg/kg/week; p.o.; in two divided doses; for 13 weeks) exerts potential anticancer activity when co-treatment with MTX (5.0 or 2.5 mg/kg/week; i.p.).
Animal Model: | 5–6 weeks Wistar strain albino male rats (150–220 g) |
Dosage: | 70 mg/kg/week (co-treatment with MTX 5.0 or 2.5 mg/kg/week) |
Administration: | Oral administration; once a week; in two divided doses; for 13 weeks |
Result: | Exerted potential anticancer activity in rats when co-treatment with MTX. |
安全信息
危险品标志 | Xn,N |
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危险类别码 | 22-50 |
安全说明 | 61 |
危险品运输编号 | UN 3077 9 / PGIII |
WGK Germany | 3 |
毒害物质数据 | 129-20-4(Hazardous Substances Data) |
羟保松 化学药品说明书
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/08/19 | HY-B1355A | Oxyphenbutazone | 5 mg | 750元 | |
2024/08/19 | HY-B1355A | 羟保松 Oxyphenbutazone | 129-20-4 | 10mg | 1200元 |