双链聚肌胞
中文名称 | 双链聚肌胞 |
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中文同义词 | 聚肌苷酸-聚胞苷酸钠盐;双链聚肌胞;卡那霉素-聚肌胞钠盐复合物;双链聚肌胞钠盐;POLYI:C双链聚肌胞钠盐;双链聚肌胞溶液;聚肌苷 - 聚胞苷酸钠盐;聚肌胞溶液(双链聚肌胞溶液) |
英文名称 | Polyinosinic-polycytidylic acid sodium salt |
英文同义词 | POLYINOSINIC ACID + POLYCYTIDYLIC ACID, SODIUM SALT;POLYINOSINIC ACID POLYCYTIDYLIC ACID, SODIUM SALT;POLYINOSINIC-POLYCYTIDYLIC ACID SODIUM SALT;POLY I POLY C, NA;POLY[I] POLY[C] SODIUM SALT;Oligochitosan-kanamycin-polyI-polyC sodium salt compound solution;Polyinosinic acid - polycytidylic acid sodium salt, double-stranded;Polyinosinic Acid . Polycytidylic Acid, Sodium Salt, Double |
CAS号 | 42424-50-0 |
分子式 | C19H27N7O16P2 |
分子量 | 671.41 |
EINECS号 | 1308068-626-2 |
相关类别 | 医药中间体;中间体;医药兽药;原料药;生化试剂-聚合物类;兽用鉰料添加剂和婴幼儿奶粉添加;Biochemicals and Reagents;Biomaterials;Cell Culture;Materials Science;Nucleosides;Nucleotides;Oligonucleotide Polymers and Copolymers;Oligonucleotides;Other adjuvants;Synthetic Oligonucleotides and Related Reagents;医药原料;化学试剂;Vaccine Adjuvants;Vaccine Production |
Mol文件 | 42424-50-0.mol |
结构式 |
双链聚肌胞 性质
储存条件 | −20°C |
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溶解度 | H2O:可溶,10mg/mL |
形态 | 冻干粉 |
颜色 | 白色至米白色 |
水溶解性 | Water : 10 mg/mL (Need ultrasonic and warming) |
TLR3, RIG-I, MDA5, apoptosis
Polyinosinic-polycytidylic acid (20 ng/mL; 24 hours; WM793, WM278, WM239A, WM9 and 1205Lu cells) treatment strongly reduces viability from 100% in controls to 20%–50% within 24 hours.
Polyinosinic-polycytidylic acid (200 ng/mL; 24 hours; 1205Lu cells) treatment induces apoptosis in 1205Lu cells.
Polyinosinic-polycytidylic acid (3 ng/mL; 24 hours; 1205Lu cells) treatment induces IFN-β expression in melanoma cells. Silencing of RIG-I and MDA-5 confirmed that induction of IFN-β by Polyinosinic-polycytidylic acid required RIG-I and MDA-5, respectively, and that required IPS-1.
Polyinosinic-polycytidylic acid (5 ng/mL; 24 hours; 1205Lu cells) treatment reveals active subunits of caspase-9 and caspase-8 in melanoma cells.
Polyinosinic-polycytidylic acid sodium is prepared for injection by resuspending in sterile saline, heating to 50 °C at a concentration of 2 mg/ml to ensure complete solubilisation and then allowing to cool naturally to room temperature to ensure proper annealing of double-stranded RNA. Poly I:C is stored at -20 °C until use.
Cell Viability Assay
Cell Line: | WM793, WM278, WM239A, WM9 and 1205Lu cells |
Concentration: | 20 ng/mL |
Incubation Time: | 24 hours |
Result: | Strongly reduced viability from 100% in controls to 20%–50% within 24 hours. |
Apoptosis Analysis
Cell Line: | 1205Lu cells |
Concentration: | 200 ng/mL |
Incubation Time: | 24 hours |
Result: | Induced apoptosis in 1205Lu cells. |
RT-PCR
Cell Line: | 1205Lu cells |
Concentration: | 3 ng/mL |
Incubation Time: | 24 hours |
Result: | Induced IFN-β expression in melanoma cells. |
Western Blot Analysis
Cell Line: | 1205Lu cells |
Concentration: | 5 ng/mL |
Incubation Time: | 24 hours |
Result: | Revealed active subunits of caspase-9 and caspase-8 in melanoma cells. |
Polyinosinic-polycytidylic acid treatment inhibits tumor growth in NOD/SCID immunodeficient mice injected with 1205Lu cells. The level of human DNA is 50% lower in mice treated with Polyinosinic-polycytidylic acid.
安全信息
安全说明 | 22-24/25 |
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WGK Germany | 3 |
RTECS号 | TR0175000 |
提供商 | 语言 |
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英文
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更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/08/19 | HY-135748 | Polyinosinic-polycytidylic acid sodium | 5 mg | 1750元 | |
2024/08/19 | HY-135748 | 双链聚肌胞 Polyinosinic-polycytidylic acid sodium | 42424-50-0 | 10mg | 2800元 |