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2-(3,4-Dihydroxy-benzylidene)-benzofuran-3-one, Sphingosine Kinase Inhibitor V

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Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:SKI-V
CAS:24418-86-8
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
Company Name: TargetMol Chemicals Inc.
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Products Intro: Product Name:SKI V
CAS:24418-86-8
Package:10 mg；100 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Aladdin Scientific
Tel: +1-833-552-7181
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Products Intro: Product Name:SKI-V
CAS:24418-86-8
Purity:99% Package:$276.9/5mg;$444.9/10mg;$1001.9/25mg;$1236.9/50mg;$1830.9/100mg;Bulk package Remarks:99%
Company Name: Shanghai Chaolan Chemical Technology Center  
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Products Intro: Product Name:SKI-V
CAS:24418-86-8
Purity:98% Package:5MG;10MG;50MG;100MG,1G,5G,100G
Company Name: Beijing Jin Ming Biotechnology Co., Ltd.  
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Products Intro: Product Name:SKI V
CAS:24418-86-8
Purity:98% Package:1mg;5mg;10mg
2-(3,4-Dihydroxy-benzylidene)-benzofuran-3-one, Sphingosine Kinase Inhibitor V Basic information
Product Name:2-(3,4-Dihydroxy-benzylidene)-benzofuran-3-one, Sphingosine Kinase Inhibitor V
Synonyms:2-(3,4-Dihydroxy-benzylidene)-benzofuran-3-one, Sphingosine Kinase Inhibitor V;SKI V;2-(3,4-Dihydroxy-benzylidene)-benzofuran-3-one;Sphingosine Kinase Inhibitor V;2-(3,4-Dihydroxybenzylidene)benzofuran-3(2H)-one;3(2H)-Benzofuranone, 2-[(3,4-dihydroxyphenyl)methylene]-;(2Z)-2-(3,4-dihydroxybenzylidene)-1-benzofuran-3(2H)-one;(2E)-2-[(3,4-dihydroxyphenyl)methylidene]-1-benzofuran-3-one
CAS:24418-86-8
MF:C15H10O4
MW:254.24
EINECS:
Product Categories:
Mol File:24418-86-8.mol
2-(3,4-Dihydroxy-benzylidene)-benzofuran-3-one, Sphingosine Kinase Inhibitor V Structure
2-(3,4-Dihydroxy-benzylidene)-benzofuran-3-one, Sphingosine Kinase Inhibitor V Chemical Properties
Boiling point 493.2±45.0 °C(Predicted)
density 1.489±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,2-8°C
solubility DMSO: 250 mg/mL (983.32 mM)
pka8.99±0.10(Predicted)
Safety Information
MSDS Information
2-(3,4-Dihydroxy-benzylidene)-benzofuran-3-one, Sphingosine Kinase Inhibitor V Usage And Synthesis
DefinitionChEBI: 3',4'-dihydroxyaurone is a hydroxyaurone that is aurone which is substituted by hydroxy groups at the 3' and 4' positions; major species at pH 7.3. It shows inhibitory activity against several isoforms of the histone deacetylase complex (HDAC). It has a role as an EC 3.5.1.98 (histone deacetylase) inhibitor. It is a hydroxyaurone and a member of catechols. It is functionally related to a 2',3,4-trihydroxy-trans-chalcone.
Biological ActivitySKI V is a non-competitive, potent non-lipid sphingosine kinase (SPHK; SK) inhibitor with IC50 of 2 μM against GST-hSK. SKI V potently inhibits PI3K with IC50 of 6 μM for hPI3k. SKI V reduces the formation of the mitotic second messenger sphingosine-1-phosphate (S1P). SKI V induces apoptosis and has antitumor activity.
in vivo

SKI V (75 mg/kg; ip; days 1, 5, 9, 15) significantly lowers tumor growth (>50% decreased at day 18) than control animals.

< td class="col2"> IP; days 1, 5, 9, 15
Animal Model: 6-8 weeks old BALB/c female mice with JC mammary adenocarcinoma cells
Dosage: 75 mg/kg
Administration:
Result: Tumor growth was significantly lower (>50% decreased at day 18) than tumor growth in control animals.
target

IC50: 2 μM (GST-hSK), 6 μM (hPI3k) and 80 μM (ERK2)

2-(3,4-Dihydroxy-benzylidene)-benzofuran-3-one, Sphingosine Kinase Inhibitor V Preparation Products And Raw materials
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