| Company Name: |
Shanghai Chaolan Chemical Technology Center
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| Tel: |
QQ:65489617 15618227136 |
| Email: |
info@SuperLan-chem.com |
| Products Intro: |
Product Name:PROTAC CDK2/9 Degrader-1
CAS:2408641-24-5
Purity:98% HPLC Package:5MG;10MG;50MG;100MG,1G,5G,500G
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| Company Name: |
cjbscvictory
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| Tel: |
13348960310 13348960310 |
| Email: |
3003867561@qq.com |
| Products Intro: |
Product Name:PROTAC CDK2
CAS:2408641-24-5
Purity:98% Package:5mg；10mg；20mg；50mg；100mg；200mg
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| | PROTAC CDK2/9 Degrader-1 Basic information |
| | PROTAC CDK2/9 Degrader-1 Chemical Properties |
| density | 1.534±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 130 mg/mL (159.34 mM; Need ultrasonic) | | pka | 10.74±0.40(Predicted) |
| | PROTAC CDK2/9 Degrader-1 Usage And Synthesis |
| Biological Activity | PROTAC CDK2/9 Degrader-1 (Compound F3) is a potent dual degrader for CDK2 (DC50=62 nM) and CDK9 (DC50=33 nM). PROTAC CDK2/9 Degrader-1 suppresses prostate cancer PC-3 cell proliferation (IC50=0.12 μM) by effectively blocking the cell cycle in S and G2/M phases. PROTAC CDK2/9 Degrader-1 is a PROTAC by tethering CDK inhibitor with CRBN ligand[1].
PROTAC CDK2/9 Degrader-1 (0.25-3 μM; 48 hours) induces cell cycle blockage at the G2/M phase[1].PROTAC CDK2/9 Degrader-1 (500 nM; 2-24 hours) down-regulates the Mcl-1 protein level in PC-3 cells[1].PROTAC CDK2/9 Degrader-1 effectively degrades CDK2/9 in cell lines MCF-7, HCT-116 and 22Rv1, which all have high CDK2/9 expression[1].PROTAC CDK2/9 Degrader-1 inhibits both CDK2 and CDK9, with IC50 as 7.42 nM and 14.50 nM, respectively[1]. | | References | [1]. Zhou F, et al. Development of selective mono or dual PROTAC degrader probe of CDK isoforms. Eur J Med Chem. 2019 Dec 6;187:111952. |
| | PROTAC CDK2/9 Degrader-1 Preparation Products And Raw materials |
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