盐酸奈替康唑
| 中文名称 | 盐酸奈替康唑 |
|---|---|
| 中文同义词 | 盐酸奈替康唑;盐酸奈康唑;盐酸萘康唑;(E)-1-(2-(甲硫基)-1-(2-(戊氧基)苯基)乙烯基)-1H-咪唑盐酸盐 |
| 英文名称 | Neticonazole Hydrochloride |
| 英文同义词 | 1-[2-methylsulfanyl-1-(2-pentoxyphenyl)ethenyl]imidazole hydrochloride;Atolant;Neticonazole hydrochloride;SS-717;1-[(E)-2-methylsulfanyl-1-(2-pentoxyphenyl)ethenyl]imidazole,hydrochloride;long-acting,colorectal,Neticonazole,antifungal,Neticonazole Hydrochloride,Imidazole,anti-cancer,nSMase2,Fungal,secretion,Inhibitor,p-ERK,anti-infection,inhibit,exosome;(E)-1-(2-(Methylthio)-1-(2-(pentyloxy)phenyl)vinyl)-1H-imidazole hydrochloride |
| CAS号 | 130773-02-3 |
| 分子式 | C17H23ClN2OS |
| 分子量 | 338.9 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 130773-02-3.mol |
| 结构式 |  |
盐酸奈替康唑 性质
| 熔点 | 145-147° |
|---|---|
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：250 mg/ml（737.68 mM） |
Fungal
Neticonazole (10 µM; 48 hours; C4-2B cells) treatment decreases the levels of both Alix and Rab27a, and significantly decreases nSMase2 levels. Neticonazole causes a significant inhibition in p-ERK levels.
Neticonazole (0-10 µM) exhibits a potent and dose-dependent inhibition of exosome release from C4-2B cells.
Neticonazole hydrochloride is also an orally active exosome biogenesis and secretion inhibitor.
Western Blot Analysis
| Cell Line: | C4-2B cells |
| Concentration: | 10 µM |
| Incubation Time: | 48 hours |
| Result: | Decreased the levels of both Alix and Rab27a, and significantly decreased nSMase2 levels. |
Neticonazole (1-100 ng/kg; oral gavage; daily; for 15 days; male C57BL/6 mice) treatment significantly improves the survival of intestinal dysbacteriosis (IDB) mice with colorectal cancer (CRC) xenograft tumors, likely through increasing apoptosis of CRC xenograft tumor cells.
| Animal Model: | Male C57BL/6 mice (8 weeks old) given ampicillin, neomycin, metronidazole and vancomycin, and injected with SW480 cells |
| Dosage: | 1 ng/kg, 10 ng/kg and 100 ng/kg |
| Administration: | Oral gavage; daily; for 15 days |
| Result: | Significantly improved the survival of IDB mice with CRC xenograft tumors. |
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-128365 | 盐酸奈替康唑 Neticonazole hydrochloride | 130773-02-3 | 25mg | 650元 |
| 2024/04/30 | S4878 | 盐酸奈替康唑 Neticonazole Hydrochloride | 130773-02-3 | 25mg | 794.46元 |