| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
Product Name:Monoclonal Anti-Human IgG (Fc specific)
Purity:monoclonal GG-7, ascites fluid Package:0.2mL, 0.5mL Remarks:I6260
|
| Company Name: |
Riedel-de Haen AG
|
| Tel: |
800 558-9160 |
| Email: |
|
| Products Intro: |
Purity:clone HP-6017, ascites fluid Remarks:clone HP-6017, purified immunoglobulin, buffered aqueous solution
|
| Company Name: |
SIGMA-RBI
|
| Tel: |
800 736 3690 (Orders) |
| Email: |
|
| Products Intro: |
|
|
| | Monoclonal Anti-Human IgG (Fc specific) Basic information |
| Product Name: | Monoclonal Anti-Human IgG (Fc specific) | | Synonyms: | Monoclonal Anti-Human IgG (Fc specific);Monoclonal Anti-Human IgG (Fc specific)-Biotin antibody produced in mouse;Monoclonal Anti-Human IgG (Fc specific)-FITC antibody produced in mouse | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![Monoclonal Anti-Human IgG (Fc specific) Structure]() |
| | Monoclonal Anti-Human IgG (Fc specific) Chemical Properties |
| | Monoclonal Anti-Human IgG (Fc specific) Usage And Synthesis |
| Uses | Monoclonal Anti-Human IgG (Fc specific)-FITC antibody produced in mouse has been used in:
- Fluorescent Dot Immunobinding Assay (F-DIBA)
- Particle Immunofluorescent Assay (F-IFMA)
- flow cytometry
| | General Description | Monoclonal Anti-Human IgG (mouse IgG2a isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. Immunoglobulins (Igs) belongs immunoglobulin super-family. Each immunoglobin have two heavy (H) and two light (L), held together by disulphide linkages. The light comprises of one variable N-terminal region and a constant C-terminal region. The heavy chain has one variable N-terminal region and three or four constant (CH1-CH4) C-terminal region. | | Biochem/physiol Actions | Digestion of IgG by papain results in generation of fragment antigen binding (Fab) comprising one complete L chain and a variable and CH1 region of H chain. Pepsin digestion of IgG results in fragment crystallisable (fc), containing the H chain constant region. IgG antibody have enormous therapeutic potential and the Fc is for the development of therapeutic antibody. Although the antibody site is located in the terminal end of the human IgG molecule (part of the Fab fragment), the Fc portion has various important functions such as complement fixation, site for rheumatoid factor (autoantibodies directed to Fc), passage through placental membrane and staphylococcus protein A binding. |
| | Monoclonal Anti-Human IgG (Fc specific) Preparation Products And Raw materials |
|