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| | N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide) Basic information |
| Product Name: | N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide) | | Synonyms: | 4',4'''-Sulfonylbis(α-chloroacetanilide);Bis[4-(chloroacetylamino)phenyl] sulfone;N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide);TC-E 5003;N,N'-(Sulfonyldi-4,1-phenylene)bis(2-chloroacetamide);N'-(Sulfonyldi-4;1-phenylene)bis(2-chloroacetamide);TC-E 5003 (NSC-30176) | | CAS: | 17328-16-4 | | MF: | C16H14Cl2N2O4S | | MW: | 401.26 | | EINECS: | | | Product Categories: | | | Mol File: | 17328-16-4.mol | ![N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide) Structure](CAS/GIF/17328-16-4.gif) |
| | N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide) Chemical Properties |
| Melting point | 191-192 °C | | Boiling point | 704.2±60.0 °C(Predicted) | | density | 1.504±0.06 g/cm3(Predicted) | | storage temp. | -20°C (des.) | | solubility | Soluble in DMSO (up to 50 mg/ml). | | form | solid | | pka | 11.56±0.70(Predicted) | | color | Brown | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. |
| | N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide) Usage And Synthesis |
| Description | TC-E 5003 is an inhibitor of protein arginine methyltransferase 1 (PRMT1; IC50 = 1.5 μM for human PRMT1 in a methylation assay). It is selective for PRMT1 over PRMT4/CARM1 and SET7/9 methyltransferases, with less than 5% inhibition at a concentration of 50 μM for SET7/9. TC-E 5003 inhibits growth of MCF-7a breast cancer and LNCaP prostate cancer cells (GI50s = 1.97 and 4.49 μM, respectively) and decreases androgen-dependent gene transcription in vitro. TC-E 5003 (80 mg/kg) also has antimalarial properties and eradicates P. berghei in mice. | | Uses | NSC 30176 is a inhibitor of human PRMT1, it is selective for PRMT1 over the arginine methyltransferase CARM1 and the lysine methyltransferase Set7/9. | | References | 1) Bissinger?et al. (2011),?Acyl derivatives of p-aminosulfonamides and dapsone as new inhibitors of the arginine methytransferase hPRMT1; Bioorg. Med. Chem.,?19?3717 |
| | N,N'-[Sulfonylbis(1,4-phenylene)]bis(chloroacetamide) Preparation Products And Raw materials |
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