| Company Name: |
J & K SCIENTIFIC LTD.
|
| Tel: |
010-82848833 400-666-7788 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:TolbutaMide-d9
CAS:1219794-57-6
Package:2.5Mg,25Mg
|
| Company Name: |
Alta Scientific Co., Ltd.
|
| Tel: |
022-6537-8550 15522853686 |
| Email: |
sales@altasci.com.cn |
| Products Intro: |
Product Name:Tolbutamide-d9
CAS:1219794-57-6
Purity:99% Package:10mg;100mg;1g
|
| Company Name: |
Nanjing Haolv Biotechnology Co.,Ltd
|
| Tel: |
025-84622273 02584622273; |
| Email: |
kexin.zhou@haolvbiotech.com |
| Products Intro: |
Product Name:Tolbutamide-d9
CAS:1219794-57-6
Purity:98%+ Package:5g;1g;500mg;100mg;25mg;10mg
|
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| | Tolbutamide-d9 Basic information |
| | Tolbutamide-d9 Chemical Properties |
| Melting point | 108-111°C | | storage temp. | Refrigerator | | solubility | DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS (pH 7.2) (1:1): 0.14 mg/ml | | form | A solid |
| | Tolbutamide-d9 Usage And Synthesis |
| Description | Tolbutamide-d9 is intended for use as an internal standard for the quantification of tolbutamide by GC- or LC-MS. Tolbutamide is an inhibitor of sulfonylurea receptor 1 (SUR1) linked to ATP-sensitive potassium channel Kir6.2 (IC50 = 4.9 μM). It is selective for SUR1/Kir6.2 over SUR2A/Kir6.2 and SUR2B/Kir6.2 channels (IC50s = 85 and 88 μM, respectively). Tolbutamide increases glucose-induced insulin secretion and calcium influx in isolated mouse pancreatic islets. In vivo, tolbutamide (80 mg/kg) reduces blood glucose levels in a mouse model of diabetes induced by streptozotocin (STZ; ). Formulations containing tolbutamide have been used in the treatment of type 2 diabetes. | | Chemical Properties | White Solid | | Uses | Labelled Tolbutamide (T535150). An antidiabetic, used as a hypoglycemic agent in veterinary medicine. |
| | Tolbutamide-d9 Preparation Products And Raw materials |
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