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EMMX Biotechnology LLC
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Product Name:LY 334370 hydrochloride CAS:199673-74-0 Purity:98% HPLC Package:5mg;10mg;25mg;50mg;100mg;250mg;500mg;1g
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| BenzaMide, 4-fluoro-N-[3-(1-Methyl-4-piperidinyl)-1H-indol-5-yl]-, Monohydrochloride Basic information |
| BenzaMide, 4-fluoro-N-[3-(1-Methyl-4-piperidinyl)-1H-indol-5-yl]-, Monohydrochloride Chemical Properties |
storage temp. | Store at -20°C | solubility | Soluble to 25 mM in water with gentle warming and to 25 mM in DMSO with gentle warming | form | Powder |
| BenzaMide, 4-fluoro-N-[3-(1-Methyl-4-piperidinyl)-1H-indol-5-yl]-, Monohydrochloride Usage And Synthesis |
Description | LY334370 is an agonist of the serotonin (5-HT) receptor subtype 5-HT1F (Kd = 0.446 nM). It is selective for 5-HT1F over other G protein-coupled 5-HT receptor subtypes with Ki values ranging from 16.4 to greater than 3,000 nM in radioligand binding assays. LY334370 inhibits forskolin-induced cAMP accumulation in mouse L-M(TK-) cell membranes expressing the recombinant human 5-HT1F receptor (EC50 = 1.51 nM). It decreases electrically stimulated extravasation of plasma proteins in the dura mater in a guinea pig trigeminal nerve model of migraine headache. | Uses | LY 334370 Hydrochloride is a 5-HT1f receptor agoniist used potentially in the treatment of migranes. |
| BenzaMide, 4-fluoro-N-[3-(1-Methyl-4-piperidinyl)-1H-indol-5-yl]-, Monohydrochloride Preparation Products And Raw materials |
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