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S0859

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Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:S0859
CAS:1019331-10-2
Purity:98% HPLC Package:5MG;10MG;50MG;100MG,1G,5G
Company Name: career henan chemical co
Tel: +86-0371-86658258
Email: sales@coreychem.com
Products Intro: Product Name:1H-Isoindole-1,3(2H)-dione, 5-[5-[[3-(4-broMophenyl)-2-iMino-4-oxo-5-thiazolidinylidene]Methyl]-2-furanyl]-
CAS:1019331-10-2
Purity:98% Package:1KG;1USD
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:S0859
CAS:1019331-10-2
Purity:99.50% Package:1 mL * 10mM (in DMSO)；10 mg；100 mg；2 mg；25 mg；5 mg；50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel: 86-571-88216897,88216896 13588875226
Email: sales@hzclap.com
Products Intro: Product Name:S0859
CAS:1019331-10-2
Purity:99% Package:10kg 25kg 200 kilograms per barrel Remarks:good
Company Name: ANHUI WITOP BIOTECH CO., LTD
Tel: +8615255079626
Email: eric@witopchemical.com
Products Intro: Product Name:1019331-10-2
CAS:1019331-10-2

S0859 manufacturers

  • S0859
  • S0859 pictures
  • $0.00 / 1gram
  • 2022-02-18
  • CAS:1019331-10-2
  • Min. Order: 1gram
  • Purity: 99%
  • Supply Ability: 10kg
S0859 Basic information
Uses
Product Name:S0859
Synonyms:2-chloro-N-[[2'-[(cyanoamino)sulfonyl][1,1'-biphenyl]-4-yl]methyl]-N-[(4-methylphenyl)methyl]- S0859;2-Chloro-N-[[2′-[(cyanoamino)sulfonyl][1,1′-biphenyl]-4-yl]methyl]-N-[(4-methylphenyl)methyl]-benzamide;2-Chloro-N-((2'-(N-cyanosulfamoyl)-[1,1'-biphenyl]-4-yl)methyl)-N-(4-methylbenzyl)benzamide;S0859;(4S)-4-HYDROXY-4-[(3R)-3-HYDROXYBUTYL]-3,5,5-TRIMETHYL-2-CYCLOHEXEN-1-ONE;100852;S 0859; S-0859; S 0859; S-0859;CS-1766
CAS:1019331-10-2
MF:C29H24ClN3O3S
MW:530.04
EINECS:
Product Categories:Inhibitors;APIs
Mol File:1019331-10-2.mol
S0859 Structure
S0859 Chemical Properties
Boiling point 748.5±70.0 °C(Predicted)
density 1.313±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: soluble10mg/mL, clear
form powder
pka-1.34±0.40(Predicted)
color white to light brown
Safety Information
WGK Germany 3
MSDS Information
S0859 Usage And Synthesis
Uses2-Chloro-N-[[2'-[(cyanoamino)sulfonyl][1,1'-biphenyl]-4-yl]methyl]-N-[(4-methylphenyl)methyl]benzamide is a selective inhibitor of sodium-bicarbonate cotransporters in mammalian heart.
DescriptionS0859 is an N-cyanosulphonamide that blocks the sodium/bicarbonate cotransporter (NBC, also known as SLC4A7), which regulates intracellular pH, particularly in myocytes. It inhibits intracellular pH recovery in myocytes with a Ki value of 1.7 μM, with full inhibition occurring at ~30 μM. S0859 does not affect other exchange proteins or enzymes that might regulate intracellular pH. It prevents changes in pH associated with depolarization and hyperpolarization of ventricular myocytes from rabbit, rat, and guinea pig. S0859 has also been used to study the role of NBC in coronary endothelial cells, cancer cells, embryonic kidney cells, and neutrophils.
Uses2-Chloro-N-[[2''-[(cyanoamino)sulfonyl][1,1''-biphenyl]-4-yl]methyl]-N-[(4-methylphenyl)methyl]benzamide is a selective inhibitor of sodium-bicarbonate cotransporters in mammalian heart.
Biochem/physiol ActionsS0859 is a selective high-affinity generic inhibitor of the Na+/HCO3- sodium bicarbonate co-transporter (NBC). S0859 does not inhibit Na+-H+ exchange (NHE).
S0859 Preparation Products And Raw materials
Tag:S0859(1019331-10-2) Related Product Information
Deionized water N,N'-Ethylenebis(stearamide) (2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride