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BioBioPha Co., Ltd.
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0871-65217109 13211707573; |
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| Products Intro: |
Product Name:4β-Hydroxywithanolide E
CAS:54334-04-2
Purity:98.0% Package:5mg Remarks:BBP04792
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| | 4beta-Hydroxywithanolide E Basic information |
| Product Name: | 4beta-Hydroxywithanolide E | | Synonyms: | 4beta-Hydroxywithanolide E;4β-Hydroxywithanolide E;Ergosta-2,24-dien-26-oic acid, 5,6-epoxy-4,14,17,20,22-pentahydroxy-1-oxo-, δ-lactone, (4β,5β,6β,17α,22R)-;4β-HydroxywithanolideE;5β,6β-epoxy-4β,14,17α,20,22R-pentahydroxy-1-oxo-ergosta-2,24-dien-26-oic acid, ?-lactone | | CAS: | 54334-04-2 | | MF: | C28H38O8 | | MW: | 502.6 | | EINECS: | | | Product Categories: | | | Mol File: | 54334-04-2.mol |  |
| | 4beta-Hydroxywithanolide E Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Chloroform: soluble; Ethanol: soluble; Methanol: soluble | | form | A crystalline solid |
| | 4beta-Hydroxywithanolide E Usage And Synthesis |
| Description | 4β-Hydroxywithanolide E is a withanolide steroidal lactone that has been found in P. peruviana and has anti-inflammatory and anticancer activities.1,2,3 It inhibits LPS-induced nitric oxide (NO) production in RAW 264.7 cells and TNF-α-induced NF-κB activity in HEK293 cells (IC50s = 0.32 and 0.04 μM, respectively).1 4β-Hydroxywithanolide E (5 μM) inhibits LPS-induced increases in inducible nitric oxide synthase (iNOS) and COX-2 levels and Akt and STAT1 phosphorylation in RAW 264.7 cells.2 It inhibits Wnt signaling in HCT116 and SW480 colorectal cancer cells (IC50s = 1.85 and 2.67 μM, respectively).3 4β-Hydroxywithanolide E inhibits the proliferation of HCT116, SW480, HT-29, and LoVo cells (IC50s = 0.24-0.51 μM). It halts the cell cycle at the G0/G1 phase in HCT116 and HT-29 cells and induces apoptosis in HCT116 and SW480 cells in a concentration-dependent manner. 4β-Hydroxywithanolide E (10 mg/kg per day for 14 days) reduces tumor growth in an HCT116 mouse xenograft model. | | Definition | ChEBI: 4beta-Hydroxywithanolide E is a withanolide. | | References | 1. Sang-Ngern, M., Youn, U.J., Park, E.J., et al. Withanolides derived from Physalis peruviana (Poha) with potential anti-inflammatory activity Bioorg. Med. Chem. Lett. 26(12),2755-2759(2016).
2. Park, E.J., Sang-Ngern, M., Chang, L.C., et al. Physalactone and 4β-hydroxywithanolide E isolated from Physalis peruviana inhibit LPS-induced expression of COX-2 and iNOS accompanied by abatement of Akt and STAT1 J. Nat. Prod. 82(3),492-499(2019).
3. Ye, Z.N., Yuan, F., Liu, J.Q., et al. Physalis peruviana-derived 4β-hydroxywithanolide E, a novel antagonist of Wnt signaling, inhibits colorectal cancer in vitro and in vivo Molecules 24(6),E1146(2019). |
| | 4beta-Hydroxywithanolide E Preparation Products And Raw materials |
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