双氯芬酸二乙胺
中文名称 | 双氯芬酸二乙胺 |
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中文同义词 | 双氯芬酸二乙胺 5G;2-(2,6-二氯苯胺)苯乙酸二乙胺盐;双氯芬酸二乙胺;2-((2,6-二氯苯基)氨基)苯乙酸二乙胺盐;双氯芬酸二乙胺盐;双氯芬酸二乙胺盐原料药;湖北双氯芬酸二乙胺盐原料药;医药级双氯芬酸二乙胺盐 |
英文名称 | Diclofenac diethylamine |
英文同义词 | 2-[(2,6-dichlorophenyl)amino]-benzeneacetic acid compd. with n-ethylethanamine;2-[2-(2,6-dichloroanilino)phenyl]acetic acid;Diclofenac diethylamine, >=99%;Benzeneacetic acid, 2-[(2,6-dichlorophenyl)amino]-, compd. with N-ethylethanamine (1:1);2-[(2,6-dichlorophenyl)amino]-benzeneacetic acid compd. with n-ethylethanamine (1:1);DICLOFENAC DIETHYLAMINE;n-ethylethanamine 2-[(2,6-dichlorophenyl)amino]benzeneacetate;Diethylammonium salt |
CAS号 | 78213-16-8 |
分子式 | C18H22Cl2N2O2 |
分子量 | 369.29 |
EINECS号 | 616-599-2 |
相关类别 | 医药原料;小分子抑制剂;解热镇痛类;神经系统用药;食品添加剂;解热镇痛;原料药;解热镇痛原料药;中间体;化合物:原料药:解热镇痛类;医药原料药;解热镇痛抗炎药;原料;科研试剂;原料;其他类;化工原料;化学试剂;API |
Mol文件 | 78213-16-8.mol |
结构式 |
双氯芬酸二乙胺 性质
熔点 | 145-148°C |
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储存条件 | Inert atmosphere,Room Temperature |
溶解度 | DMF:30mg/mL; DMSO:10mg/mL;乙醇:30mg/mL; PBS(pH 7.2):2 mg/mL |
形态 | 结晶固体 |
颜色 | 白色至米白色 |
稳定性 | 吸湿性 |
CAS 数据库 | 78213-16-8(CAS DataBase Reference) |
Human COX-2 1.3 nM (IC 50 , in CHO cells) |
Human COX-1 4 nM (IC 50 , in CHO cells) |
Ovine COX-2 0.84 μM (IC 50 ) |
Ovine COX-1 5.1 μM (IC 50 ) |
Diclofenac diethylamine抗炎,退热,和镇痛作用的主要作用机制被认为是通过抑制环氧合酶(COX),从而抑制前列腺素合成。它通过抑制细菌DNA合成发挥出抑菌活性。COX的抑制也会减少胃上皮细胞中的前列腺素,使其对胃酸的腐蚀更敏感。这也是diclofenac diethylamine的主要副作用。Diclofenac diethylamine阻断COX2-同工酶(大约10倍),具有低到中度的选择性,因此,diclofenac diethylamine造成的胃肠疾病的发生率比消炎痛和阿司匹林低。
Diclofenac (3 mg/kg, b.i.d., for 5 days) significantly increases faecal
51
Cr excretion in rats, and such effect is also observed in squirrel monkeys after administrated of 1 mg/kg twice daily for 4 days.
Diclofenac (10 mg/kg; administered via oral route just prior to induction of inflammation) shows in vivo anti-inflammatory activity in Wistar rats.
Animal Model: | Male Sprague-Dawley rats (150±200 g) |
Dosage: | 3 mg/kg |
Administration: | Oral administration, b.i.d., for 5 days |
Result: | Resulted in a significant increase in faecal 51 Cr excretion. |
Animal Model: | Wistar rats (150-175 g) bearing Formalin-induced rat foot paw edema model |
Dosage: | 10 mg/kg |
Administration: | Administered via oral route just prior to induction of inflammation |
Result: | Showed in vivo anti-inflammatory activity (% edema inhibition=29.2, 1 h; 22.2, 3 h; 20, 6 h). |
安全信息
双氯芬酸二乙胺 化学药品说明书
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/08/19 | HY-15036A | 双氯芬酸二乙胺 Diclofenac diethylamine | 78213-16-8 | 500mg | 350元 |
2024/08/19 | HY-15036A | 双氯芬酸二乙胺 Diclofenac diethylamine | 78213-16-8 | 5G | 484元 |