蒲公英萜醇
中文名称 | 蒲公英萜醇 |
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中文同义词 | 蒲公英赛醇(标准品);蒲公英萜醇;蒲公英赛烷醇;3Β-塔罗沙酚;(3Β)-D-FRIEDOOLEAN-14-EN-3-OL;植物来源:蒲公英;3Β-塔罗沙酚;(3S,4AR,6AR,8AR,12AR,12BS,14AR,14BR)-4,4,6A,8A,11,11,12B,14B-八甲基-1,2,3,4,4A,5,6,6A,8,8A,9,10,11,12,12A,12B,13,14,14A,14B-二十氢苉-3-醇 |
英文名称 | taraxerol |
英文同义词 | Alnulin;D-Friedoolean-14-en-3β-ol;Skimmiol;Tiliadin;(3β)-D-Friedoolean-14-en-3-ol;(3β13α)-13-Methyl-27-norolean-14-en-3-ol;3β-Taraxerol;Taraxero |
CAS号 | 127-22-0 |
分子式 | C30H50O |
分子量 | 426.73 |
EINECS号 | |
植物来源 | 蒲公英 |
相关类别 | 标准品;对照品;中药对照品;植物提取物;三萜;标准品 -中药标准品 |
Mol文件 | 127-22-0.mol |
结构式 |
蒲公英萜醇 性质
熔点 | 282-285° |
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沸点 | 490.7±44.0 °C(Predicted) |
密度 | 1.01±0.1 g/cm3(Predicted) |
储存条件 | 4°C, protect from light |
溶解度 | ≥ 40 mg/mL,溶于 DMSO |
酸度系数(pKa) | 15.19±0.70(Predicted) |
形态 | 固体 |
颜色 | 白色 |
水溶解性 | insoluble in water |
LogP | 11.060 (est) |
IC50: apoptosis
Taraxerol (0-100 μM; 24 or 48 hours)significantly reduces cell viability to 95% (20 μM), 89.8% (40 μM), 82.6 % (60 μM), 72.9 % (80 μM), and 63.6% (100 μM).And this compound has cell viability of 90.7% at a concentration of 20 μM and 53.6% at the 100 μM concentration at 48 hours in Hela cells. Taraxerol (80 μM; 24 or 48 hours) induces Hela cells apoptosis and cell death in a dose-dependent manner.Taraxerol can induce a significant apoptosis of cells by annexin V/ PI double staining, significant increase in both the early (24.2%) and late (16.2%) stages of apoptotic cells compared with the control group at the early (6.5%) and late (0.5%) stages.
Taraxerol (5 and 10mg/kg; i.p.) attenuates carrageenan induced paw edema 2h onward. The effect of taraxerol at the dose of 5mg/kg is found to be significant (p<0.05) only after 4h of carrageenan treatment.
安全信息
WGK Germany | 3 |
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