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3-[1-[[(3μ-nitro[1,1μ-biphenyl]-4-yl)oxy]methyl]-3-(4-pyridinyl)propyl]-2,4-thiazolidinedione

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3-[1-[[(3μ-nitro[1,1μ-biphenyl]-4-yl)oxy]methyl]-3-(4-pyridinyl)propyl]-2,4-thiazolidinedione Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:AZ 11645373；3-[1-[[(3'-NITRO[1,1'-BIPHENYL]-4-YL)OXY]METHYL]-3-(4-PYRIDINYL)PROPYL]-2,4-THIAZOLIDINEDIONE
CAS:227088-94-0
Package:1 mg；10 mg；100 mg；200 mg；25 mg；5 mg；50 mg；500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Aladdin Scientific
Tel: +1-833-552-7181
Email: sales@aladdinsci.com
Products Intro: Product Name:AZ 11645373
CAS:227088-94-0
Purity:>=98%(HPLC) Package:$33.9/1mg;$129.9/5mg;$332.9/10mg;$448.9/25mg;$1199.9/50mg;$1472.9/100mg;Bulk pac Remarks:98%(HPLC)
Company Name: J & K SCIENTIFIC LTD.  
Tel: 010-82848833 400-666-7788
Email: jkinfo@jkchemical.com
Products Intro: Product Name:AZ 11645373
CAS:227088-94-0
Package:100Mg,10Mg,50Mg,5Mg
Company Name: 3B Pharmachem (Wuhan) International Co.,Ltd.  
Tel: 821-50328103-801 18930552037
Email: 3bsc@sina.com
Products Intro: Product Name:AZ 11645373;3-[1-[[(3'-Nitro[1,1'-biphenyl]-4-yl)oxy]Methyl]-3-(4-pyridinyl)propyl]-2,4-thiazolidinedione
CAS:227088-94-0
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
Company Name: Shanghai TaoSu Biochemical Technology Co., Ltd.  
Tel: 021-33632979
Email: info@tsbiochem.com
Products Intro: Product Name:AZ 11645373
CAS:227088-94-0
Purity:90% Package:5Mg;10Mg;50Mg;100Mg
3-[1-[[(3μ-nitro[1,1μ-biphenyl]-4-yl)oxy]methyl]-3-(4-pyridinyl)propyl]-2,4-thiazolidinedione Basic information
Product Name:3-[1-[[(3μ-nitro[1,1μ-biphenyl]-4-yl)oxy]methyl]-3-(4-pyridinyl)propyl]-2,4-thiazolidinedione
Synonyms:3-[1-[[(3μ-nitro[1,1μ-biphenyl]-4-yl)oxy]methyl]-3-(4-pyridinyl)propyl]-2,4-thiazolidinedione;AZ11645373;1'-BIPHENYL]-4-YL)OXY]METHYL]-3-(4-PYRIDINYL)PROPYL]-2;3-[1-[[(3'-NITRO[1;4-THIAZOLIDINEDIONE;2,4-Thiazolidinedione, 3-[1-[[(3'-nitro[1,1'-biphenyl]-4-yl)oxy]methyl]-3-(4-pyridinyl)propyl]-;3-(1-((3'-nitro-[1,1'-biphenyl]-4-yl)oxy)-4-(pyridin-4-yl)butan-2-yl)thiazolidine-2,4-dione;3-(1-((3'-nitro-[1,1'-biphenyl]-4-yl)oxy)-4-(pyridin-4-yl)butan-2-yl)thiazolidine-2,4-dione
CAS:227088-94-0
MF:C24H21N3O5S
MW:463.512
EINECS:
Product Categories:Aromatics, Heterocycles, Neurochemicals
Mol File:227088-94-0.mol
3-[1-[[(3μ-nitro[1,1μ-biphenyl]-4-yl)oxy]methyl]-3-(4-pyridinyl)propyl]-2,4-thiazolidinedione Structure
3-[1-[[(3μ-nitro[1,1μ-biphenyl]-4-yl)oxy]methyl]-3-(4-pyridinyl)propyl]-2,4-thiazolidinedione Chemical Properties
Boiling point 689.1±65.0 °C(Predicted)
density 1.362±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: ≥10mg/mL
form solid
pka5.95±0.10(Predicted)
color tan
Safety Information
Hazard Codes Xi
Risk Statements 37/38-41
Safety Statements 26-39
WGK Germany 3
MSDS Information
3-[1-[[(3μ-nitro[1,1μ-biphenyl]-4-yl)oxy]methyl]-3-(4-pyridinyl)propyl]-2,4-thiazolidinedione Usage And Synthesis
UsesA selective P2X7 receptor antagonist.
Biological ActivityPotent and selective human P2X 7 antagonist (K B values are 5 - 7 and > 10,000 nM at hP2X 7 and rP2X 7 respectively) that is completely without effect at all other P2X subtypes. Inhibits BzATP-mediated calcium influx and inhibits ATP-mediated IL-1 β release in vitro (K B values are 15 and 92 nM respectively).
storageStore at +4°C
references1. stokes l, jiang lh, alcaraz l, et al. characterization of a selective and potent antagonist of human p2x(7) receptors, az11645373. british journal of pharmacology. 2006;149(7):880-887.
3-[1-[[(3μ-nitro[1,1μ-biphenyl]-4-yl)oxy]methyl]-3-(4-pyridinyl)propyl]-2,4-thiazolidinedione Preparation Products And Raw materials
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