| Company Name: |
J & K SCIENTIFIC LTD.
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| Tel: |
010-82848833 400-666-7788 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:AP-18
CAS:55224-94-7
Package:25Mg,50Mg,5Mg
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| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:AP 18;4-(4-Chlorophenyl)-3-Methyl-3-buten-2-oneoxiMe
CAS:55224-94-7
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| Company Name: |
Sigma-Aldrich
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| Tel: |
021-61415566 800-8193336 |
| Email: |
orderCN@merckgroup.com |
| Products Intro: |
Product Name:AP-18
CAS:55224-94-7
Purity:>=98% (HPLC), solid Package:5MG Remarks:A7232-5MG
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| | 4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime Basic information |
| Product Name: | 4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime | | Synonyms: | AP-18;4-(4-Chlorophenyl)-3-methyl-3-buten-2-oneoxime;4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime;3-Buten-2-one, 4-(4-chlorophenyl)-3-methyl-, oxime;4-(4-Chlorophenyl)-3-methylbut-3-en-2-one oxime;ganglia,TRP Channel,nerves,pain,AP18,Transient receptor potential channels,AP-18,AP 18,inhibit,nociceptive,root,hyperalgesia,Inhibitor,transduction,dorsal | | CAS: | 55224-94-7 | | MF: | C11H12ClNO | | MW: | 209.67 | | EINECS: | | | Product Categories: | Aromatics, Pharmaceuticals, Intermediates & Fine Chemicals | | Mol File: | 55224-94-7.mol |  |
| | 4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime Chemical Properties |
| storage temp. | 2-8°C | | solubility | DMSO: >10mg/mL | | form | solid | | color | white to off-white | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months. |
| Hazard Codes | Xn | | Risk Statements | 22 | | WGK Germany | 3 |
| | 4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime Usage And Synthesis |
| Description | AP-18 is a channel blocker which reversibly inhibits TRPA1 (IC50s = 3.1 and 4.5 μM, human and mouse, respectively). It has minimal effect on TRPV1-4 or TRPM8. AP-18 has been used to study TRPA1 signaling in mice and rats as well as in vitro. | | Uses | AP-18 is a selective TRPA1 channel blocker. AP-18 blocks the transient receptor potential ankyrin 1 receptors and can reduce chronic pain associated with arthritis. AP-18 reduces cinnamaldehyde-induced nociception in vivo and blocks cold- and mustard oil-induced activation of mouse TRPA1 but not capsaicin-induced activation. AP-18 reverses CFA-induced mechanical hyperalgesia in mice | | Uses | AP-18 is a channel blocker that inhibits TRPA1. | | Biological Activity | Reversible TRPA1 channel blocker (IC 50 values are 3.1 and 4.5 μ M at human and mouse TRPA1 respectively). Blocks cinnameldehyde-induced but not capsaicin-induced nociception and reverses mechanical hyperalgesia in vivo . Also blocks TRPA1 pore dilation (IC 50 = 10.3 μM for the inhibition of Yo-Pro uptake). | | Biochem/physiol Actions | AP-18 is a selective TRPA1 channel blocker. Transient receptor potential A1 (TRPA1) plays a central role for chemical sensing in the pain pathway. AP-18 is a novel TRPA1 channel blocker. It reduces cinnamaldehyde-induced nociception in vivo and blocks cold- and mustard oil-induced activation of mouse TRPA1 but not capsaicin-induced activation demonstrating selectivity vs. TRPV11. AP-18 reverses CFA-induced mechanical hyperalgesia in mice. | | in vivo | ap-18 blocks the transient receptor potential ankyrin 1 receptors and can reduce chronic pain associated with arthritis. this product is also capable to induce cinnamaldehyde-induced nociception and to block cold- and mustard oil-induced activation of mouse trpa1 but not capsaicin-induced activation 2. in addition, ap18 treatment reversed cfa-induced mechanical hyperalgesia in mice 2. thus, trpa1 is essential for sensitization of nociception. | | storage | +4°C | | References | References”Citations: |
| | 4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime Preparation Products And Raw materials |
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