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| | D-erythro-C18-Dihydro-D-sphingosine Basic information |
| | D-erythro-C18-Dihydro-D-sphingosine Chemical Properties |
| Melting point | 70-72°C | | Boiling point | 446.2±25.0 °C(Predicted) | | density | 0.927±0.06 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | DMSO: soluble25mg/mL (warm) | | pka | 12.57±0.45(Predicted) | | form | White to off-white solid. | | color | white | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
| | D-erythro-C18-Dihydro-D-sphingosine Usage And Synthesis |
| Description | Dihydrosphingosine (764-22-7) is a biosynthetic precursor of sphingosine. Inhibitor of protein kinase C1?and phospholipases A2 and D2. | | Chemical Properties | White Powder | | Uses | Sphinganine (d18:0) has been used:
- as a standard in liquid chromatography tandem mass spectrophotometry for the quantification of epidermal ceramides
- as a medium supplement to test its effect on growth of yeast cells
- in the preparation of bovine serum albumin lipid complex to investigate its effect on non-lysosomal - glucosylceramidase β2 (GBA2) inhibition
| | Uses | Biosynthetic precursor of Sphingosine. Inhibits protein kinase C. | | Definition | ChEBI: Sphinganine is a 2-aminooctadecane-1,3-diol having (2S,3R)-configuration. It has a role as an EC 2.7.11.13 (protein kinase C) inhibitor, a human metabolite and a mouse metabolite. It is a conjugate base of a sphinganine(1+). | | General Description | Sphinganine (d18:0) is a substrate for the enzyme ceramide desaturase. It is synthesized indirectly due to the interconversion of supplemented glycine to serine. Sphinganine (d18:0) is catabolized to ceramide. | | Biochem/physiol Actions | Sphinganine (d18:0) levels are not altered in hereditary sensory neuropathy type 1 cells. Accumulation of d18:0 is observed in tumor hypoxia. It is useful as a biomarker for studying microbial diversity. | | References | 1) Merrill?et al. (1989),?Structural requirements for long-chain (sphingoid) base inhibition of protein kinase C in vitro and for cellular effects of these compounds; Biochemistry,?28?3138
2) Franson?et al. (1992),?Sphingolipid metabolism and signal transduction: inhibition of in vitro phospholipase activity by sphingosine, Biochim. Biophys. Acta?1136?169 |
| | D-erythro-C18-Dihydro-D-sphingosine Preparation Products And Raw materials |
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