Z-VAL-ALA-ASP-(OH)-FLUOROMETHYL KETONE
| 中文名称 | Z-VAL-ALA-ASP-(OH)-FLUOROMETHYL KETONE |
|---|---|
| 中文同义词 | PAN-CASPASE抑制剂;(5S,8S,11S)-11-(2-氟乙酰基)-5-异丙基-8-甲基-3,6,9-三氧代-1-苯基-2-氧杂-4,7,10-三氮杂十三烷13-酸;化合物Z-VAD(OH)-FMK;CASPASE抑制剂VI CALBIOCHEM;Z-VAD(OH)-FMK(半胱天冬酶抑制剂VI) |
| 英文名称 | Z-Vad-fmk, non-methylated |
| 英文同义词 | Z-VAL-ALA-ASP-(OH)-FLUOROMETHYL KETONE;Z-VAD-FMK (Caspase Inhibitor VI);Carbobenzyloxy-Val-Ala-Asp-alpha-fluoromethylketone;L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-1-(carboxymethyl)-3-fluoro-2-oxopropyl]-;L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-valyl-N-[(1S)-1-(carboxymethyl)-3-fluoro-2-oxopropyl]- (9ci);L-Alaninamide, N-[(phenylmethoxy)carbonyl]-L-valyl-N-[1-(carboxymethyl)-3-fluoro-2-oxopropyl]-, (S)-;Z-VAD-FMK, Free Acid;Z-VAD(OH)-FMK (Caspase Inhibitor VI) |
| CAS号 | 161401-82-7 |
| 分子式 | C21H28FN3O7 |
| 分子量 | 453.46 |
| EINECS号 | |
| 相关类别 | Caspase 抑制剂 |
| Mol文件 | 161401-82-7.mol |
| 结构式 |  |
Z-VAL-ALA-ASP-(OH)-FLUOROMETHYL KETONE 性质
| 沸点 | 758.0±60.0 °C(Predicted) |
|---|---|
| 密度 | 1.260±0.06 g/cm3(Predicted) |
| 储存条件 | -20°C |
| 溶解度 | DMSO:5.0(最大浓度 mg/mL);11.0(最大浓度 mM) |
| 酸度系数(pKa) | 3.91±0.19(Predicted) |
| 形态 | 类白色固体 |
Z-VAD-FMK (Z-VAD(OH)-FMK) 是一种 pan caspase 抑制剂。Z-VAD-FMK 不抑制泛素 C 末端水解酶 L1 (UCHL1) 活性，即使浓度高达 440 μM。
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Caspase
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Z-VAD-FMK (40 μM) reverses the apoptotic effect exerted by total saponin of Solanum lyratum Thunb (TSSLT) in Hela cells. HeLa cells are pretreated with Z-VAD-FMK (40 μM) for 30 min and exposed to TSSLT (6 μg/mL) for 48 h.
Cell Viability Assay
| Cell Line: | HeLa cells |
| Concentration: | 40 μM |
| Incubation Time: | Prtreated for 30 minutes |
| Result: | Prevented TSSLT-induced cell death. More than 80% cell survival was observed. |