| Company Name: |
ChengDu Yijierui Biotechnology CO., Ltd Gold
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18224018291 17345243906 |
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3004072879@qq.com |
| Products Intro: |
Product Name:Guvacoline Hydrobromide
CAS:17210-51-4
Purity:98% HPLC Package:10mg;20mg;50mg;100mg
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| Company Name: |
J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788 |
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jkinfo@jkchemical.com |
| Products Intro: |
Product Name:Guvacoline HydrobroMide
CAS:17210-51-4
Package:100Mg,10Mg
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| Company Name: |
ChemStrong Scientific Co.,Ltd
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| Tel: |
0755-0755-66853366 13670046396 |
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sales@chem-strong.com |
| Products Intro: |
Product Name:Guvacoline hydrobromide
CAS:17210-51-4
Purity:95% HPLC Package:10mg;25mg;50mg;100mg
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| | Guvacoline Hydrobromide Basic information |
| Product Name: | Guvacoline Hydrobromide | | Synonyms: | 1,2,5,6-Tetrahydro-3-pyridinecarboxylic Acid Methyl Ester HydrobroMide;1,2,5,6-tetrahydro-3-pyridinecarboxylic acid, methyl ester, monohydrobromide | | CAS: | 17210-51-4 | | MF: | C7H12BrNO2 | | MW: | 222.07968 | | EINECS: | | | Product Categories: | Amines;Heterocycles;Intermediates & Fine Chemicals;Nicotine Derivatives;Pharmaceuticals;Amines, Heterocycles, Nicotine Derivatives, Pharmaceuticals, Intermediates & Fine Chemicals | | Mol File: | 17210-51-4.mol |  |
| | Guvacoline Hydrobromide Chemical Properties |
| Melting point | 144°C | | storage temp. | -20°C Freezer | | solubility | ≤1mg/ml in DMSO;1mg/ml in dimethyl formamide | | form | crystalline solid |
| | Guvacoline Hydrobromide Usage And Synthesis |
| Chemical Properties | Crystalline Solid | | Uses | A muscarinic receptor used as nootropic agent. | | Biological Activity | guvacoline is a kind of natural alkaloid which is found in areca nuts that is related to the nootropic, arecoline. guvacoline can function as a full agonist of atrial and ileal muscarinic receptors.in vitro: in human buccal epithelial cells, guvacoline could significantly decrease the colony-formation efficiency in a dose dependent manner, with the ic50 value of 2.1 mm. besides, guvacoline could also dose-dependently reduce the amount of total free low-molecular-weight thiols (0.88 mm guvacoline caused 25% decrease) and increase the number of single strand breaks [1]. | | target | atrial and ileal muscarinic receptors | | IC 50 | 2.1 mm for growth inhibition of human buccal epithelial cells | | references | [1] k. sundqvist, y. liu, j. nair, et al. cytotoxic and genotoxic effects of areca nut-related compounds in cultured human buccal epithelial cells. cancer research 49(19), 5294-5298 (1989). |
| | Guvacoline Hydrobromide Preparation Products And Raw materials |
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