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(S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride

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(S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:PF-04859989 HCl；PF-04859989;PF-04859989HCl;PF04859989;PF 04859989
CAS:177943-33-8
Package:1 mL * 10mM (in DMSO)；10 mg；100 mg；2 mg；200 mg；25 mg；5 mg；50 mg；500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Labnetwork lnc.
Tel: +86-27-50766799 +8618062016861
Email: contact@labnetwork.com
Products Intro: Product Name:(3S)-3-amino-1-hydroxy-3,4-dihydroquinolin-2-one;hydrochloride
CAS:177943-33-8
Purity:95% Package:1kg+
Company Name: Aladdin Scientific
Tel: +1-833-552-7181
Email: sales@aladdinsci.com
Products Intro: Product Name:PF-04859989 hydrochloride
CAS:177943-33-8
Purity:98% (HPLC) Package:$86.9/5mg;$271.9/25mg;Bulk package Remarks:98% (HPLC)
Company Name: Shanghai Aladdin Bio-Chem Technology Co.,LTD  
Tel: 18521735133 18521732826;
Email: market@aladdin-e.com
Products Intro: Product Name:PF-04859989 hydrochloride
CAS:177943-33-8
Purity:98% (HPLC) Package:25mg/RMB 3822.90;5mg/RMB 913.90
Company Name: Sigma-Aldrich  
Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Products Intro: Product Name:PF-04859989
CAS:177943-33-8
Purity:>=98% (HPLC) Package:5mg, 25mg Remarks:PZ0250
(S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride Basic information
Product Name:(S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride
Synonyms:(S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride;(3S)-3-Amino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one;L-3-Amino-3,4-dihydro-1-hydroxycarbstyril hydrochloride;PF04859989 hydrochloride;PF-04859989 hydrochloride;PF-4859989 hydrochloride;PF 04859989 hydrochloride - L-3-Amino-3,4-dihydro-1-hydroxycarbstyril hydrochloride;PF-04859989 hydrochloride >=98% (HPLC)
CAS:177943-33-8
MF:C9H11ClN2O2
MW:214.64884
EINECS:
Product Categories:
Mol File:177943-33-8.mol
(S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride Structure
(S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride Chemical Properties
storage temp. room temp
solubility H2O: soluble20mg/mL, clear
form powder
color white to beige
Water Solubility Water: 22 mg/ml
Safety Information
MSDS Information
(S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride Usage And Synthesis
Biochem/physiol ActionsPF-04859989 is a brain-penetrable irreversible inhibitor of kynurenine amino transferase II (KAT II), the enzyme responsible for most of the brain synthesis of kynurenic acid, which has been implicated in several psychiatric and neurological disorders, including schizophrenia and bipolar disorder, and thought to impair cognitive function. PF-04859989 has IC50 values of 23 nM for hKAT II and 263 nM for rKAT II. PF-04859989 is ~1000-fold selective for KAT II over human KAT I, KAT III, and KAT IV. PF-04859989 prevented ketamine-induced disruption of performance in memory tasks in both rodents and nonhuman primates.
(S)-3-aMino-1-hydroxy-3,4-dihydroquinolin-2(1H)-one hydrochloride Preparation Products And Raw materials
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