氧化苏木精
中文名称 | 氧化苏木精 |
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中文同义词 | 海尔丹;苏木红;苏木因;天然黑1;氧化苏木红;氧化苏木精;氧化苏木素 |
英文名称 | HEMATEIN |
英文同义词 | TIMTEC-BB SBB006464;HEMATEIN FOR MICROSCOPY;LABOTEST-BB LT00441274;HYDROXYBRASILEIN;HEMATEIN;HAEMATEIN;2-d)pyran-9(6h)-one,6a,7-dihydro-3,4,6a,10-tetrahydroxy-benz(b)indeno(;2-d]pyran-9(6h)-one,6a,7-dihydro-3,4,6a,10-tetrahydroxy-benz[b]indeno[ |
CAS号 | 475-25-2 |
分子式 | C16H12O6 |
分子量 | 300.26 |
EINECS号 | 207-492-8 |
相关类别 | 分析试剂-染料中间体;G-H-I;Stains and Dyes;Stains&Dyes, A to |
Mol文件 | 475-25-2.mol |
结构式 |
氧化苏木精 性质
熔点 | 180 °C |
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沸点 | 361.5°C (rough estimate) |
密度 | 1.2766 (rough estimate) |
折射率 | 1.4600 (estimate) |
储存条件 | 2-8°C |
溶解度 | 少许溶于甲醇 |
形态 | 结晶粉末 |
色指数 | 75290 |
酸度系数(pKa) | 8.02±0.40(Predicted) |
颜色 | 深棕色 |
水溶解性 | 0.6g/L(20 ºC) |
Merck | 13,4651 |
BRN | 93039 |
LogP | 0.560 (est) |
EPA化学物质信息 | Benz[b]indeno[1,2-d]pyran-9(6H)-one, 6a,7-dihydro-3,4,6a,10-tetrahydroxy- (475-25-2) |
CKII 0.74 μM (IC 50 ) |
Akt
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Wnt
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Hematein (10-100 μM; 14 days) inhibits cells growth in A427 lung cancer cells.
Hematein (50 and 100 μM; 48 hours) induces apoptosis in A427 lung cancer cells.
Hematein (50 and 100 μM; 48 hours) inhibits CK2-specific Akt phosphorylation.
Cell Viability Assay
Cell Line: | A427 (HTB-53) cell line |
Concentration: | 10-100 μM |
Incubation Time: | 14 days |
Result: | Inhibited cells growth. |
Apoptosis Analysis
Cell Line: | A427 (HTB-53) cell line |
Concentration: | 50 and 100 μM |
Incubation Time: | 48 hours |
Result: | Induced apoptosis in A427 lung cancer cells. |
Western Blot Analysis
Cell Line: | A427 (HTB-53) cell line |
Concentration: | 50 and 100 μM |
Incubation Time: | 48 hours |
Result: | Inhibited CK2-specific Akt phosphorylation. |
Hematein (intraperitoneal injections; 50 mg/kg; twice a week for 6 weeks) inhibits tumor growth in A427 lung cancer cell xenografts.
Animal Model: | Female athymic BALB/c nude mice (6-week-old) |
Dosage: | 50 mg/kg |
Administration: | Intraperitoneal injections; twice a week for 6 weeks |
Result: | Inhibited tumor growth in A427 lung cancer cell xenografts. |
提供商 | 语言 |
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英文
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英文
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