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| | 3,4-Dimethoxyphenethylamine Basic information |
| | 3,4-Dimethoxyphenethylamine Chemical Properties |
| Melting point | 12-15 °C | | Boiling point | 188 °C15 mm Hg(lit.) | | density | 1.074 g/mL at 25 °C(lit.) | | vapor pressure | 0.348-0.348Pa at 25℃ | | refractive index | n20/D 1.546(lit.) | | Fp | >230 °F | | storage temp. | Refrigerator | | solubility | Chloroform (Slightly), Methanol (Slightly) | | form | Viscous Liquid | | pka | 9.74±0.10(Predicted) | | Specific Gravity | 1.10 | | color | Clear light yellow to orange or slightly brownish | | PH | 11.4 (100g/l, H2O, 20℃) | | explosive limit | 0.1-1.7%(V) | | Water Solubility | SOLUBLE | | Sensitive | Air Sensitive | | InChIKey | ANOUKFYBOAKOIR-UHFFFAOYSA-N | | LogP | 0.77 | | CAS DataBase Reference | 120-20-7(CAS DataBase Reference) | | NIST Chemistry Reference | Benzeneethanamine, 3,4-dimethoxy-(120-20-7) | | EPA Substance Registry System | Benzeneethanamine, 3,4-dimethoxy- (120-20-7) |
| Hazard Codes | Xn,Xi | | Risk Statements | 22-36/37/38 | | Safety Statements | 26-36-37/39 | | RIDADR | UN 2735 | | WGK Germany | 3 | | RTECS | SH2300000 | | F | 10 | | Hazard Note | Irritant | | TSCA | Yes | | HazardClass | 8 | | PackingGroup | III | | HS Code | 29222900 | | Toxicity | mouse,LD50,intraperitoneal,181mg/kg (181mg/kg),Yakugaku Zasshi. Journal of Pharmacy. Vol. 97, Pg. 1117, 1977. |
| | 3,4-Dimethoxyphenethylamine Usage And Synthesis |
| Chemical Properties | 3,4-Dimethoxyphenethylamine is clear yellowish oil | | Uses | 3,4-Dimethoxyphenethylamine is a methylated metabolite of Dopamine (D533780); a potent inhibitor of brain mitochondrial respiration used in Parkinson’s disease studies. | | Uses | A methylated metabolite of Dopamine (D533780); a potent inhibitor of brain mitochondrial respiration used in Parkinson’s disease studies. | | Uses | Precursor for the synthesis of isoquinolines. | | Definition | ChEBI: An aromatic ether that is the derivative of 2-phenylethylamine with methoxy substituents at the 3- and 4-positions. It is an alkaloid isolated from the Cactaceae family. | | Flammability and Explosibility | Not classified | | Safety Profile | Poison by intravenous
and intraperitoneal routes. When heated to
decomposition it emits toxic fumes of NOx. | | Purification Methods | Purify the amine by fractionation through an efficient column in an inert atmosphere as it is a relatively strong base. [Horner & Sturm Justus Liebigs Ann Chem 608 12819 1957, Jung et al. J Am Chem Soc 75 4664 1953.] The hydrochloride has m 152o, 154o, 156o (from EtOH, Me2CO or EtOH/Et2O), the picrate has m 165-167o(dec), and the 4-nitrobenzoyl derivative has m 147o [Buck J Am Chem Soc 55 2593 1933]. [Beilstein 13 H 800, 13 IV 2604.] |
| | 3,4-Dimethoxyphenethylamine Preparation Products And Raw materials |
| Raw materials | (3,4-Dimethoxyphenyl)acetonitrile | | Preparation Products | Verapamil-->Fenoldopam-->DOPEXAMINE-->DOBUTAMINE-->Desmethyl-5'-methoxylaudanosine-->Tetrahydropapaverine hydrochloride-->(R)-1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinoline-->TETRABENAZINE-->6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride-->[2-(3,4-DIMETHOXY-PHENYL)-ETHYL]-(5-METHYL-FURAN-2-YLMETHYL)-AMINE-->N-(3,4-DIMETHOXYPHENETHYL)ACETAMIDE-->1-(3,4-DIMETHOXYPHENETHYL)-5-OXO-3-PYRROLIDINECARBOXYLIC ACID-->4-(6,7-DIMETHOXY-1,2,3,4-TETRAHYDRO-ISOQUINOLIN-1-YL)-PHENOL-->Benzamide, N-[2-(3,4-dimethoxyphenyl)ethyl]-2-hydroxy- |
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