- RSL3
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- $1.00 / 1KG
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2019-12-20
- CAS:1219810-16-8
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 100kgs
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| Product Name: | RSL3 | | Synonyms: | RSL3;RSL3 (1S,3R-);1S,3R-RSL3;CS-2409;methyl (1S,3R)-2-(2-chloroacetyl)-1-(4-methoxycarbonylphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-3-carboxylate;RSL 3;RSL-3;RSL3 1S;3R-;1S;3R-RSL3;3R-RSL3 | | CAS: | 1219810-16-8 | | MF: | C23H21ClN2O5 | | MW: | 440.88 | | EINECS: | | | Product Categories: | API | | Mol File: | 1219810-16-8.mol |  |
| Boiling point | 641.3±55.0 °C(Predicted) | | density | 1.368±0.06 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Store in freezer, under -20°C | | solubility | Soluble in DMSO (45 mg/ml) | | pka | 16.09±0.60(Predicted) | | form | solid | | color | Off-white | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
| Description | RSL3 (1219810-16-8) Inhibits glutathione peroxidase (GPX4) inducing ferroptosis.1,2? Effectively induces ferroptosis in glioblastoma cells.3? Everolimus in combination with RSL3 synergistically inhibits the viability of renal cell carcinoma (RCC) cells suggesting a mechanism by which RCC drug resistance may be overcome.4 | | in vitro | rsl3, which was a glutathione peroxidase (gpx) 4 inhibitor, had been cooperated with the smac mimetic bv6 to induce reactive oxygen species (ros)-dependent cell death in acute lymphoblastic leukemia cells. it was found that addition of the caspase inhibitor failed to rescue ros-induced cell death, suggesting that rsl3-induced cell death occured in a caspase-independent manner. moreover, the iron chelator deferoxamine inhibited rsl3/bv6-induced cell death significantly, however, it could not rescue cell death by erastin/bv6, indicating that rsl3/bv6-, but not erastin/bv6-mediated cell death depended on iron. in addition, it was shown that ros production was required for both rsl3/bv6- and erastin/bv6-induced cell death. in contrast, genetic or pharmacological inhibition of lipid peroxidation by gpx4 overexpression significantly decreased rsl3/bv6-induced cell death. of importance, inhibition of lipid peroxidation could protect from rsl3/bv6-stimulated ros production [1]. | | IC 50 | 100 nm | | storage | Store at -20°C | | References | Yang et al. (2014), Regulation of ferroptotic cancer cell death by GPX4; Cell 156 317
Kagan et al. (2017), Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis; nAT. Chem. Biol. 13 81
Shengbiao et al. (2021), RSL3 Drives Ferroptosis through NF-kB Pathway Activation and GPX4 depletion in Glioblastoma; oXID. Med. Cell. Longev. 2021 2915019
Yangyun et al. (2022), Everolimus accelerates Erastin and RSL3-induced ferroptosis in renal cell carcinoma; Gene 809 145992 |
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