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| | NSC781406 Basic information |
| Product Name: | NSC781406 | | Synonyms: | NSC781406;NSC781406;NSC-781406;NSC 781406;NSC-781406;NSC 781406;Benzenesulfonamide, 2,4-difluoro-N-[2-methoxy-5-[4-[3-[4-(methylsulfonyl)-1-piperazinyl]-1-propyn-1-yl]-6-quinolinyl]-3-pyridinyl]-;NSC781406,Phosphoinositide 3-kinase,NSC 781406,NSC-781406,PI3K,Mammalian target of Rapamycin,Inhibitor,inhibit,mTOR | | CAS: | 1676893-24-5 | | MF: | C29H27F2N5O5S2 | | MW: | 627.68 | | EINECS: | | | Product Categories: | | | Mol File: | 1676893-24-5.mol |  |
| | NSC781406 Chemical Properties |
| Boiling point | 775.1±70.0 °C(Predicted) | | density | 1.52±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 10mg/mL; DMSO: 20mg/mL; DMSO:PBS (pH 7.2) (1:4): 0.2mg/mL | | form | A solid | | pka | 6.23±0.40(Predicted) |
| | NSC781406 Usage And Synthesis |
| Description | NSC 781406 is a dual inhibitor of PI3K and mammalian target of rapamycin (mTOR; IC50s = 2.0, 9.4, 2.7, 14, and 5.4 nM for PI3Kα, PI3Kβ, PI3Kγ, PI3Kδ, and mTOR, respectively). It inhibits cell growth in the NCI-60 panel of cancer cell lines (mean GI50 = 65 nM). NSC 781406 (30 mg/kg) reduces tumor volume in a BEL-7404 hepatic cancer mouse xenograft model. |
| | NSC781406 Preparation Products And Raw materials |
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