糠酸二氯尼特
| 中文名称 | 糠酸二氯尼特 |
|---|---|
| 中文同义词 | 糠二氯散;糠酯酰胺;二氯尼特糠酸酯;三呋喃亞甲基二胺;三糠醛縮二胺;4-(N-甲基-2,2-二氯乙酰氨基)苯基 2-糠酸酯;糠酸二氯尼特;糠酸二氟尼特 |
| 英文名称 | Diloxanide furoate |
| 英文同义词 | 2,2-DICHLORO-N-(4-HYDROXYPHENYL)-N-METHYLACETAMIDE 2-FUROIC ACID ESTER;DILOXANIDE FUROATE;2-furancarboxylicacid,4-((dichloroacetyl)methylamino)phenylester;2-furoicacid,esterwith2,2-dichloro-4’-hydroxy-n-methylacetanilide;8073cb;amebiazol;dichlofurazol;diclofurazol |
| CAS号 | 3736-81-0 |
| 分子式 | C14H11Cl2NO4 |
| 分子量 | 328.15 |
| EINECS号 | 223-108-1 |
| 相关类别 | 化工原料;对照品 |
| Mol文件 | 3736-81-0.mol |
| 结构式 |  |
糠酸二氯尼特 性质
| 熔点 | 111-114 °C |
|---|---|
| 沸点 | 438.4±45.0 °C(Predicted) |
| 密度 | 1.424±0.06 g/cm3(Predicted) |
| 储存条件 | 2-8°C |
| 溶解度 | 可溶于氯仿（少许）、甲醇（少许） |
| 形态 | 固体 |
| 酸度系数(pKa) | -0?+-.0.50(Predicted) |
| 颜色 | 灰白色至浅米色 |
| BCS Class | 4 |
| CAS 数据库 | 3736-81-0(CAS DataBase Reference) |
Diloxanide furoate 是二苯氧尼特的前药。Diloxanide furoate 是一种有效的具有口服活性的抗原虫制剂 (anti-protozoal agent)，可用于阿米巴病、轻度肠道阿米巴病或无症状包囊带菌感染的相关研究。
Diloxanide furoate (1.95-2.5 μg/ml) has potent activity against different strains of E. histolytica , it is against BYso (grown with bacteria), SFL3 (grown with Chrithidia sp.), and SFL3 (grown axenically) with MIC values of 2.5 μg/ml, 2.5 μg/ml and 1.95 μg/ml, respectively.
Diloxanide furoate (oral administraion; 75-200 mg/kg; 3 days; once daily) is effective at different dose of dayin weanling rats. At 200 mg/kg, 100% of the treated rats are cured and no amoebic lesions are observed in the caecum. Besides, 85%,77%, and 44.4% of the treated rats are cured at the dose 150 mg/kg, 100 mg/kg, and 75 mg/kg, respectively. The ED 50 value is 77.9 mg/kg for this agent in rats.
| Animal Model: | Weanling Wistar rats |
| Dosage: | 200 mg/kg; 150 mg/kg; 100 mg/kg; 75 mg/kg |
| Administration: | Oral administraion; 75-200 mg/kg; 3 days; once daily |
| Result: | Was against intestinal (caecal) amoebiasis in rats. |
安全信息
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英文
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