| Company Name: |
MDP ChemControl Ltd.
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| Tel: |
+421 2 62412268 |
| Email: |
chemcontrol@nextra.sk |
| Products Intro: |
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| | BENAZEPRIL HCL Basic information |
| Product Name: | BENAZEPRIL HCL | | Synonyms: | alpha-hydroxy-alpha-phenyl-benzeneaceticaci2-(ethylpropylamino)ethyles;ap1288;benapryzinehydrochloride;benzilicacid,2-(ethylpropylamino)ethylester,hydrochloride;brl1288;Benapryzine HCl;Benaprizine Hydrochloride | | CAS: | 3202-55-9 | | MF: | C24H29ClN2O5 | | MW: | 460.95 | | EINECS: | | | Product Categories: | | | Mol File: | 3202-55-9.mol |  |
| | BENAZEPRIL HCL Chemical Properties |
| | BENAZEPRIL HCL Usage And Synthesis |
| Originator | Brizin,Beecham,UK,1973 | | Uses | Anticholinergic. | | Manufacturing Process | A methanolic solution of sodium methoxide [from sodium (0.2 gram) and dry
methanol (3 ml)] was added dropwise during 20 minutes to a boiling solution
of methyl α,α-diphenylglycollate (11 grams) and 2-ethylpropylaminoethanol (6
grams) in light petroleum (150 ml, BP 80°-100°C) and the methanol that
separated was removed by using a Dean and Starke apparatus. At the end of
5 hours no further separation of methanol occurred and the reaction mixture
after being washed with water (3 x 20 ml) was extracted with 1N hydrochloric
acid (3 x 30 ml).
The acid extracts (after washing with 50 ml ether) were made alkaline with
aqueous 5 N sodium hydroxide solution, the liberated base was extracted into
ether (4 x 50 ml) and the ether extracts were dried (MgSO4). Treatment of
the extracts with hydrogen chloride gave the hydrochloride (11 grams, 70%),
which was obtained as rectangular plates, MP 164° to 166°C, after several
crystallizations from butanone. | | Therapeutic Function | Anticholinergic, Antiparkinsonian |
| | BENAZEPRIL HCL Preparation Products And Raw materials |
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