(7aS,9E)-9-Ethylidene-5,6,7,7aα,8,8aα,9,10-octahydro-12β-hydroxyindolo[3,2,1-ij]pyrano[3,4-b][1,5]naphthyridine-12aα(12H)-carboxylic acid methyl ester Suppliers list
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| (7aS,9E)-9-Ethylidene-5,6,7,7aα,8,8aα,9,10-octahydro-12β-hydroxyindolo[3,2,1-ij]pyrano[3,4-b][1,5]naphthyridine-12aα(12H)-carboxylic acid methyl ester Basic information |
Product Name: | (7aS,9E)-9-Ethylidene-5,6,7,7aα,8,8aα,9,10-octahydro-12β-hydroxyindolo[3,2,1-ij]pyrano[3,4-b][1,5]naphthyridine-12aα(12H)-carboxylic acid methyl ester | Synonyms: | (7aS,9E)-9-Ethylidene-5,6,7,7aα,8,8aα,9,10-octahydro-12β-hydroxyindolo[3,2,1-ij]pyrano[3,4-b][1,5]naphthyridine-12aα(12H)-carboxylic acid methyl ester;Talbotine;Indolo[3,2,1-ij]pyrano[3,4-b][1,5]naphthyridine-12a(12H)-carboxylic acid, 9-ethylidene-5,6,7,7a,8,8a,9,10-octahydro-12-hydroxy-, methyl ester, (7aS,8aS,9E,12R,12aS)- | CAS: | 30809-15-5 | MF: | C21H24N2O4 | MW: | 368.43 | EINECS: | | Product Categories: | | Mol File: | 30809-15-5.mol | |
| (7aS,9E)-9-Ethylidene-5,6,7,7aα,8,8aα,9,10-octahydro-12β-hydroxyindolo[3,2,1-ij]pyrano[3,4-b][1,5]naphthyridine-12aα(12H)-carboxylic acid methyl ester Chemical Properties |
Melting point | 212°C | Boiling point | 576.0±50.0 °C(Predicted) | density | 1.44±0.1 g/cm3(Predicted) | pka | 12.03±0.40(Predicted) |
| (7aS,9E)-9-Ethylidene-5,6,7,7aα,8,8aα,9,10-octahydro-12β-hydroxyindolo[3,2,1-ij]pyrano[3,4-b][1,5]naphthyridine-12aα(12H)-carboxylic acid methyl ester Usage And Synthesis |
Description | This alkaloid which has been obtained from the leaves of Pleiocarpa talbotii
Wernham contains a secondary N(b) atom and a cyclic hemiacetal group. It is
strongly laevorotatory having [α]>D - 200° (CHC13). A secondary hydroxyl
group is present and the base forms an O-methyl ether, m.p. 155-6°C. The
O,N-diacetyl derivative is also crystalline with m.p. 190-3°C. Catalytic hydrogena_x0002_tion leads to 19: 2D-dihydrota1botine. When treated with NaOMe and NaOH the
alkaloid yields two products, a lactone and a hydroxymethy1 compound in
which the hemiacetal ring is opened. These data, together with the infrared and
NMR spectra, lead to the complete relative stereochemistry of the alkaloid. | References | Pinar et al., Helv. Chim. Acta, 54, 15 (1971) |
| (7aS,9E)-9-Ethylidene-5,6,7,7aα,8,8aα,9,10-octahydro-12β-hydroxyindolo[3,2,1-ij]pyrano[3,4-b][1,5]naphthyridine-12aα(12H)-carboxylic acid methyl ester Preparation Products And Raw materials |
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