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| Product Name: | PIK-75 | | Synonyms: | 2-Methyl-5-nitro-1-benzenesulfonic acid 2-[(6-bromoimidazo[1,2-a]pyridin-3-yl)methylene]-1-methylhydrazide;PIK-75 Hydrochloride;Benzenesulfonic acid, 2-Methyl-5-nitro-, 2-[(6-broMoiMidazo[1,2-a]pyridin-3-yl)Methylene]-1-Methylhydrazide;PIK75(HCl salt);PI3-Kinase a Inhibitor VIII;PIK 75;CS-669;PIK-75, free base | | CAS: | 372196-67-3 | | MF: | C16H14BrN5O4S | | MW: | 452.28 | | EINECS: | | | Product Categories: | Inhibitors;Antineoplastic | | Mol File: | 372196-67-3.mol |  |
| | PIK-75 Chemical Properties |
| Melting point | >203°C (dec.) | | density | 1.66±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Heated) | | form | Solid | | pka | 2.08±0.50(Predicted) | | color | Light Yellow to Yellow |
| | PIK-75 Usage And Synthesis |
| Uses | PIK-75 is a p110α inhibitor, isoform-specific mutants at Ser773, and also potently inhibits DNA-PK. | | Definition | ChEBI: N-[(6-bromo-3-imidazo[1,2-a]pyridinyl)methylideneamino]-N,2-dimethyl-5-nitrobenzenesulfonamide is a sulfonamide. | | Enzyme inhibitor | This novel phosphoinositide-3 kinase p110α inhibitor (F.Wt. = 488.74; CAS 372196-67-3; Solubility (25°C): 98 mg/mL DMSO, <1 mg/mL Water), also known as (E)-N'-((6-bromoH-imidazo[1,2-a]pyridin-3-yl)methylene)-N,2- dimethyl-5-nitrobenzenesulfonohydrazide-HCl, competes with respect to a substrate (phosphatidylinositol, PI), unlike most other PI3K inhibitors, which bind at or near the ATP site. PIK-75 exhibits impressive isoform selectivity, with an IC50 value of 5.8 nM for p110α, while the corresponding IC50 values are 1300 nM, 76 nM and 510 nM for p110β, p110γ, and p110δ, respectively. |
| | PIK-75 Preparation Products And Raw materials |
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