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| | 3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide Basic information |
| Product Name: | 3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide | | Synonyms: | N-(3-Bromophenyl)-3-[(hexahydro-1H-azepin-1-yl)sulfonyl]-benzamide;SIRT2 Inhibitor,AK-7;N-(3-Bromophenyl)-3-[(hexahydro-1H-azepin-1-yl)sulfonyl]-benzamide SIRT2 Inhibitor,AK-7;AK 7, >=98%;3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide;AK-7;Benzamide, N-(3-bromophenyl)-3-[(hexahydro-1H-azepin-1-yl)sulfonyl]-;AK-7;AK7;AK 7 | | CAS: | 420831-40-9 | | MF: | C19H21BrN2O3S | | MW: | 437.35 | | EINECS: | | | Product Categories: | | | Mol File: | 420831-40-9.mol |  |
| | 3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide Chemical Properties |
| density | 1.469±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,2-8°C | | solubility | DMSO: ≥15mg/mL | | form | powder | | pka | 12.28±0.70(Predicted) | | color | white to tan | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months. |
| Hazard Codes | Xi | | Risk Statements | 36 | | Safety Statements | 26 | | WGK Germany | 3 |
| | 3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide Usage And Synthesis |
| Description | The sirtuin SIRT2 is a deacetylase which targets α-tubulin, histone 4, forkhead transcription factors, and several other substrates. It has roles in metabolic diseases, cancer, age-related disorders, and neurodegenerative diseases, potentially including Alzheimer’s, Huntington’s, and Parkinson’s diseases. AK-7 is a cell- and brain-permeable inhibitor of SIRT2 (IC50 = 15.5 μM). In culture, it diminishes neuronal cell death induced by mutant huntingtin fragment. In addition, AK-7 down-regulates cholesterol biosynthetic gene expression and reduces total cholesterol levels in neurons in vivo. | | Uses | AK-7 is a deacetylase which targets α-tubulin, histone 4, forkhead transcription factors, and several other substrates it is also a selective SIRT2 inhibitor. | | storage | +4°C | | References | 1) Tylor et al. (2011), A brain-permeable small molecule that reduces neuronal cholesterol by inhibiting activity of sirtuin 2 deacetylase; ACS Chem. Biol., 6 540
2) Chopra et al. (2012), The sirtuin 2 inhibitor AK-7 is neuroprotective in Huntington’s disease mouse models; Cell Rep., 2 1492 |
| | 3-(azepan-1-ylsulfonyl)-N-(3-broMophenyl)benzaMide Preparation Products And Raw materials |
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