C-(1H-INDOL-5-YL)-METHYLAMINE

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C-(1H-INDOL-5-YL)-METHYLAMINE Basic information
Product Name:C-(1H-INDOL-5-YL)-METHYLAMINE
Synonyms:5-(aminomethyl)-indol;INDOLE-5-METHYLAMINE;C-(1H-INDOL-5-YL)-METHYLAMINE;(1H-INDOL-5-YL)METHANAMINE;5-(AMINOMETHYL)INDOLE;(1H-Indol-5-yl)methylamine;1H-Indole-5-MethanaMine;Indole-5-methanamine
CAS:81881-74-5
MF:C9H10N2
MW:146.19
EINECS:
Product Categories:pharmacetical;Building Blocks;Heterocyclic Building Blocks;Indoles;Building Blocks;C7 to C9;Chemical Synthesis;Heterocyclic Building Blocks;Amines;Aromatics;Heterocycles;Inhibitors;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:81881-74-5.mol
C-(1H-INDOL-5-YL)-METHYLAMINE Structure
C-(1H-INDOL-5-YL)-METHYLAMINE Chemical Properties
Melting point 114-118 °C
Safety Information
Hazard Codes Xn
Risk Statements 22-36/37/38
Safety Statements 26-36
WGK Germany 3
RTECS NL4461500
MSDS Information
ProviderLanguage
SigmaAldrich English
C-(1H-INDOL-5-YL)-METHYLAMINE Usage And Synthesis
UsageReactant for preparation of:• ;HIV-1 integrase inhibitors targeting the catalytic domain and its ability for interaction with LEDGF/p751• ;Inhibitors of Gli1-mediated transcription in the Hedgehog pathway2• ;SCIO-469-like compounds for the inhibition of p38 MAP kinase3• ;4-(indol-5-ylamino)thieno[2,3-b]pyridine-5-carbonitriles as protein kinase c theta (PKC θ) inhibitors4• ;Non-covalent thrombin inhibitors5
Usage5-(Aminomethyl)indole is used in the synthesis of Vigabatrin (V253000) bioisosteres as inhibitors of γ-aminobutyric acid aminotransferase (GABA-AT) inhibitors.
C-(1H-INDOL-5-YL)-METHYLAMINE Preparation Products And Raw materials
Raw materialsLithium aluminium hydride-->Sodium cyanide-->Ethylenediamine-->COPPER(I) CYANIDE-->1-Methyl-2-pyrrolidinone -->5-Bromoindole
Tag:C-(1H-INDOL-5-YL)-METHYLAMINE(81881-74-5) Related Product Information
C-(6-BENZYLOXYMETHYL-1H-INDOL-3-YL)-METHYLAMINE STAUROSPORINE C-(6,7,8,9-TETRAHYDRO-5 H-CARBAZOL-3-YL)-METHYLAMINE OTAVA-BB BB7012240202 FROVATRIPTAN CHEMBRDG-BB 5573168 N,N-DIPROPYL-5-CARBOXAMIDOTRYPTAMINE MALEATE GO 6976 Rizatriptan benzoate K-252A 4'-demethylamino-4'-hydroxystaurosporine 2-CHLORO-N-(2,3-DIMETHYL-1H-INDOL-5-YLMETHYL)-ACETAMIDE TAN 999 2,3-DIMETHYL-1 H-INDOLE-5-CARBOXYLIC ACID HYDRAZIDE 5-carboxamidotryptamine maleate salt N-ethoxycarbonyl-7-oxostaurosporine K-252C 5-CARBOXAMIDOTRYPTAMINE, [1,2-3H]-