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DBCO-PEG4-amine

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DBCO-PEG4-amine Suppliers list
Company Name: Henan Fengda Chemical Co., Ltd
Tel: +86-371-86557731 +86-13613820652
Email: info@fdachem.com
Products Intro: Product Name:DBCO-PEG4-amine
CAS:1255942-08-5
Purity:99% Package:1KG;6USD|25KG;5USD|100KG;1USD
Company Name: 9i LLC
Tel: +18039569191
Email: MWan@NiNeiLab.com
Products Intro: Product Name:Azadibenzocyclooctyne-PEG4-amine; DBCO-PEG4-NH2; DBCO-NH-PEG4-CH2CH2NH2
CAS:1255942-08-5
Purity:97% Package:100mg;500mg;1g;5g;10g Remarks:JA1494
Company Name: career henan chemical co
Tel: +86-0371-86658258
Email: sales@coreychem.com
Products Intro: Product Name:DBCO-PEG4-amine
CAS:1255942-08-5
Purity:97%-99% Package:1KG;8.8USD
Company Name: Chongqing Chemdad Co., Ltd
Tel: +86-023-6139-8061 +86-86-13650506873
Email: sales@chemdad.com
Products Intro: Product Name:DBCO-PEG4-amine
CAS:1255942-08-5
Purity:0.98 Package:1kg，2kg，5kg，10kg，25kg
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:DBCO-NHCO-PEG4-amine
CAS:1255942-08-5
Purity:98.00% Package:100 mg；500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY

DBCO-PEG4-amine manufacturers

  • DBCO-PEG4-amine
  • DBCO-PEG4-amine pictures
  • $6.00 / 1KG
  • 2024-03-29
  • CAS:1255942-08-5
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: g-kg-tons, free sample is available
  • DBCO-PEG4-amine
  • DBCO-PEG4-amine pictures
  • $8.80 / 1KG
  • 2019-07-14
  • CAS: 1255942-08-5
  • Min. Order: 1KG
  • Purity: 97%-99%
  • Supply Ability: 100kg
DBCO-PEG4-amine Basic information
Product Name:DBCO-PEG4-amine
Synonyms:DBCO-PEG4-amine;Azadibenzocyclooctyne-PEG4-amine;DBCO-NH-PEG4-CH2CH2NH2;DBCO-PEG4-NH2;3-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]-N-[3-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-3-oxopropyl]propanamide;DBCO-PEG4 amine (ADIBO-PEG4-amine);DBCO-NHCOPEG4-amine;DBCO-NHCO-PEG4-amine TFA salt
CAS:1255942-08-5
MF:C29H37N3O6
MW:523.62
EINECS:
Product Categories:peg
Mol File:1255942-08-5.mol
DBCO-PEG4-amine Structure
DBCO-PEG4-amine Chemical Properties
Boiling point 784.1±60.0 °C(Predicted)
density 1.23±0.1 g/cm3(Predicted)
storage temp. -20°C Freezer, Under inert atmosphere
solubility Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka15.14±0.46(Predicted)
form Solid
color Yellow to Dark Yellow
Water Solubility Soluble in water.
Safety Information
MSDS Information
DBCO-PEG4-amine Usage And Synthesis
DescriptionDBCO-NHCO-PEG4-amine is a carboxyl-reactive building block with extended PEG spacer arm. The hydrophilic PEG spacer arm improves water solubility. In the presence of of activators (e.g. EDC, or HATU), this reagent can be used to derivatize carboxyl groups or activated esters (e.g. The NHS ester) through a stable amide bond. DBCO is commonly used for copper-free Click Chemistry reactions.
Biological ActivityDBCO-NHCO-PEG4-amine is a PROTAC linker and belongs to the PEG class. It is a cleavable ADC linker that can be used to link MMAE (HY-15162) to antibodies such as DBCO-VCpAB-MMAE and DBCO-TRX-MMAE, with EC50 for SKBR3 cells, respectively 280 nM and 22 nM).
in vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

target

Cleavable

PEGs

DBCO-PEG4-amine Preparation Products And Raw materials
Tag:DBCO-PEG4-amine(1255942-08-5) Related Product Information
Dacarbazine DIBENZAZEPINE DBCO-maleimide DBCO-PEG4-Acid DBCO-PEG3-amine DBCO-PEG5-CH2CH2COOH DBCO-PEG4-maleimide BDP FL DBCO DBCO-PEG4-TAMRA 2-(4-Ethyl-1-piperazinyl)-4-[4-(4-ethyl-1-piperazinyl)phenyl]-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine DBCO-PEG4-biotin DBCO-amine