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| Product Name: | ML335 | | Synonyms: | ML335; ML-335; ML 335; TREK-1/2 ACTIVATOR;TREK-1/2 Activator;Benzamide, N-[(2,4-dichlorophenyl)methyl]-4-[(methylsulfonyl)amino]-;Potassium Channel,ML-335,ML 335,ML335,KcsA,Inhibitor,inhibit | | CAS: | 825658-06-8 | | MF: | C15H14Cl2N2O3S | | MW: | 373.25 | | EINECS: | | | Product Categories: | | | Mol File: | 825658-06-8.mol |  |
| | ML335 Chemical Properties |
| storage temp. | -20° | | solubility | Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 20 mg/ml with warming). | | form | solid | | color | White | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months. |
| | ML335 Usage And Synthesis |
| Description | Two-pore domain potassium (K2P) channels of the TREK subfamily regulate neuronal excitability, influence pain, temperature perception and responses to anesthetics. ML-335 (825658-06-8) is a novel, selective TREK-1,2 activator with EC50s of 14.3 and 5.2 μM.1?It represents an important new pharmacological tool for studying the physiology of TREK channels. | | Uses | ML335, is a selective activator of both TREK-1 and TREK-2. | | storage | Store at +4°C | | References | 1) Lolicato?et al.?(2017),?K2P2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site; Nature,?547?364 |
| | ML335 Preparation Products And Raw materials |
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