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| | UAMC-3203 Basic information |
| Product Name: | UAMC-3203 | | Synonyms: | UAMC3203;UAMC 3203;UAMC-3203;inhibit,Ferroptosis,Inhibitor,UAMC-3203;Benzenesulfonamide, 4-(cyclohexylamino)-3-[(phenylmethyl)amino]-N-[2-(1-piperazinyl)ethyl]-;(S)-L-Cystine- | | CAS: | 2271358-64-4 | | MF: | C25H37N5O2S | | MW: | 471.66 | | EINECS: | | | Product Categories: | | | Mol File: | 2271358-64-4.mol |  |
| | UAMC-3203 Chemical Properties |
| Boiling point | 668.3±65.0 °C(Predicted) | | density | 1.214±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Ethanol: Soluble | | form | A crystalline solid | | pka | 12.27±0.50(Predicted) |
| | UAMC-3203 Usage And Synthesis |
| Biological Activity | UAMC-3203 is a ferroptosis inhibitor with IC50 of 10 nM in IMR-32 neuroblastoma cells. | | in vitro | UAMC-3203 was incubated with human microsomes or rat microsomes, and the T 1/2 were 20.5 h and 16.5 h, respectively. When co-incubated with mouse microsomes, UAMC-3203 showed relatively poor stability, with a T 1/2 of 3.46 h. | | in vivo | In mice, UAMC-3203 can significantly reduce the plasma concentration of lactate dehydrogenase. After administration, it is rapidly removed from the blood and enters various tissues. Significant levels of UAMC-3203 were detected in the tissues tested, such as liver, kidney and lung. | | target | | Target | Value | Ferroptosis
(IMR-32 neuroblastoma cells) | < td style="border-bottom: 1px dotted #ccc;padding: 5px;"> 10 nM
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| | UAMC-3203 Preparation Products And Raw materials |
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