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Guangzhou PI PI Biotech Inc
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+86-020-81716320 +86-13602409664 |
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Product Name:Carvedilol-d5
CAS:929106-58-1
Purity:90%+ Package:10mg, 25mg, 50mg, 100mg, Other scale please email Sales@pipitech.com Remarks:1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol-d5
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| Company Name: |
Cato Research Chemicals Inc.
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020-81960175 |
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min.he@cato-chem.com |
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Product Name:Carvedilol-d5
Purity:95% Package:25Mg, 50Mg
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| Company Name: |
Clearsynth Canada Inc.
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+1.415.685.4395 |
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enquiry@clearsynth.com |
| Products Intro: |
Product Name:Carvedilol-D5
CAS:929106-58-1
Package:10mg Remarks:CS-O-06468
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| Company Name: |
PI & PI BIOTECH INC.
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020-81716320 17788709170 |
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Sales@pipitech.com |
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CAS:929106-58-1
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| | CARVEDILOL-D5 Basic information |
| Product Name: | CARVEDILOL-D5 | | Synonyms: | CARVEDILOL-D5;1-(9H-carbazol-4-yloxy)-1,1,2,3,3-pentadeuterio-3-[2-(2-methoxyphenoxy)ethylamino]propan-2-ol;Carvedilol-D5Q: What is
Carvedilol-D5 Q: What is the CAS Number of
Carvedilol-D5 Q: What is the storage condition of
Carvedilol-D5 Q: What are the applications of
Carvedilol-D5;Carvedilol-d5 N’-?-D-Glucuronide | | CAS: | 929106-58-1 | | MF: | C24H21D5N2O4 | | MW: | 411.51 | | EINECS: | | | Product Categories: | Isotope | | Mol File: | Mol File |  |
| | CARVEDILOL-D5 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 5 mg/ml | | form | A solid |
| | CARVEDILOL-D5 Usage And Synthesis |
| Description | Carvedilol-d5 is intended for use as an internal standard for the quantification of carvedilol by GC- or LC-MS. Carvedilol is a non-selective antagonist of the β-adrenergic receptor (β-AR; Kds = 1.78, 0.4, and 5.01 nM for β1-, β2-, and β3-ARs, respectively). It also binds to α1-, but not α2-, adrenergic receptors (Kis = 0.81 and 3,400 nM, respectively). Carvedilol reverses increases in heart rate induced by the β1-AR agonist isoproterenol in isolated guinea pig atria (Kb = 0.8 nM) and induces relaxation of isolated precontracted guinea pig trachea (Kb = 1.3 nM). It prevents epinephrine-induced premature ventricular beats in a rat model of arrhythmia with an ED50 value of 0.25 mg/kg. Carvedilol also inhibits the contractile response to the α1-AR agonist norepinephrine in isolated rabbit aorta (Kb = 11 nM). It decreases systolic blood pressure and heart rate in rat models of hypertension, including spontaneously hypertensive, renal hypertensive, and deoxycorticosterone acetate-treated rats when administered at doses ranging from 3 to 30 mg/kg. Carvedilol also activates cardioprotective signaling through β-arrestin and ERK1/2 activation. Formulations containing carvedilol have been used in the treatment of congestive heart failure and hypertension. | | Chemical Properties | White Solid | | Uses | Carvedilol-d5 is the labelled analog of Carvedilol, a nonselective β-adrenergic blocker with α1-blocking activity. Carvedilol is an antihypertensive used in the treatment of congestive heart failure. | | Uses | Labeled Carvedilol, intended for use as an internal standard for the quantification of Carvedilol by GC- or LC-mass spectrometry. |
| | CARVEDILOL-D5 Preparation Products And Raw materials |
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