帕布昔利布杂质23
中文名称 | 帕布昔利布杂质23 |
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中文同义词 | 4-[6-[(6-溴-8-环戊基-7,8-二氢-5-甲基-7-氧代吡啶并[2,3-D]嘧啶-2-基)氨基]-3-吡啶基]-1-哌嗪羧酸叔丁酯;4-[6-[(6-溴-8-环戊基-7,8-二氢-5-甲基-7-氧代吡啶并[2,3-D]嘧啶-2-基)氨基]-3-吡啶;帕布昔利布中间体1;4-[6-[(6-溴-8-环戊基-7,8-二氢-5-甲基-7-氧代吡啶并[2,3-D]嘧啶-2-基)氨基]-3-吡啶基]-1-哌嗪羧酸叔丁酯 哌泊塞克雷布中间体 1KG;4-[6-(6-溴-8-环戊基-5-甲基-7-氧代-7,8-二氢吡啶并[2,3-D]嘧啶- 2-基氨基)-吡啶-3-基]-哌嗪-1-羧酸叔丁酯;帕布昔利布中间体6;(3E)-1-(2-氯乙酰基)-2,3-二氢-3-(甲氧基苯基亚甲基)-2-氧代-1H-吲哚-6-羧酸甲酯;帕布昔利布中间体一 |
英文名称 | 4-[6-(6-BROMO-8-CYCLOPENTYL-5-METHYL-7-OXO-7,8-DIHYDRO-PYRIDO[2,3-D]PYRIMIDIN-2-YLAMINO)-PYRIDIN-3-YL]-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER |
英文同义词 | 4-[6-(6-BROMO-8-CYCLOPENTYL-5-METHYL-7-OXO-7,8-DIHYDRO-PYRIDO[2,3-D]PYRIMIDIN-2-YLAMINO)-PYRIDIN-3-YL]-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;1-Piperazinecarboxylic acid, 4-[6-[(6-broMo-8-cyclopentyl-7,8-dihydro-5-Methyl-7-oxopyrido[2,3-d]pyriMidin-2-yl)aMino]-3-pyridinyl]-, 1,1-diMethylethyl ester;tert-butyl 4-{6-[(6-bromo-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino]pyridin-3-yl}piperazine-1-carboxylat;tert-butyl 4-[6-[(6-bromo-8-cyclopentyl-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]pyridin-3-yl]piperazine-1-carboxylate;tert-Butyl 4-(6-((6-bromo-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl);Palbociclib Intermediate 4;Palbociclib-016;tert-butyl 4-[6-({6-bromo-8-cyclopentyl-5-methyl-7-oxo-7H,8H-pyrido[2,3-d]pyrimidin-2-yl}amino)pyrid |
CAS号 | 571188-82-4 |
分子式 | C27H34BrN7O3 |
分子量 | 584.51 |
EINECS号 | 1592732-453-0 |
相关类别 | 帕博西布中间体;帕博西尼中间体;帕布昔利布中间体;医药中间体;科研精品试剂;日用化学品;Palbociclib;PD 0332991;Anticancer;对照品-杂质对照品;杂质对照品 |
Mol文件 | Mol File |
结构式 |
帕布昔利布杂质23 性质
熔点 | >250℃ |
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沸点 | 720.0±70.0 °C(Predicted) |
密度 | 1.439±0.06 g/cm3(Predicted) |
储存条件 | 2-8°C(protect from light) |
酸度系数(pKa) | 5.24±0.10(Predicted) |
InChIKey | UTSOLZWQDXJQRH-UHFFFAOYSA-N |
SMILES | N1(C(OC(C)(C)C)=O)CCN(C2=CC=C(NC3=NC=C4C(C)=C(Br)C(=O)N(C5CCCC5)C4=N3)N=C2)CC1 |
帕布昔利布杂质23是帕布昔利的杂质,是辉瑞公司开发的治疗乳腺癌的实验药物。它是细胞周期素依赖性激酶CDK4和CDK6的选择性抑制剂。此外,它衍生自6-溴-2-氯-8-环戊基-5-甲基吡啶-[2,3-d]嘧啶-7(8H)-酮, 用于制备吡啶基[2,3-d]嘧啶-7(8H)-酮衍生物,作为CDK4和/或用于治疗疾病的CDK6抑制剂。