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| waltonitone Basic information |
Product Name: | waltonitone | Synonyms: | waltonitone;product/153019;waltonitone USP/EP/BP;Urs-12-en-3-one, 28-hydroxy- | CAS: | 1252676-55-3 | MF: | C30H48O2 | MW: | 440.7 | EINECS: | | Product Categories: | | Mol File: | 1252676-55-3.mol | |
| waltonitone Chemical Properties |
Boiling point | 521.6±50.0 °C(Predicted) | density | 1.05±0.1 g/cm3(Predicted) | storage temp. | Store at -20°C | solubility | DMSO: 15 mg/mL (34.04 mM);; | pka | 15.09±0.10(Predicted) |
| waltonitone Usage And Synthesis |
Uses | Waltonitone is a pentacyclic triterpenoid compound isolated from waltonione. Some studies shown that Waltonitone is a potential anti-tumor drug which can inhibit the proliferation of lung cancer A549 cells and promote their apoptosis. | Biological Activity | Waltonitone is a kind of ursane-type pentacyclic triterpenes that can be extracted from the long-stemmed chinensis, which has antitumor activity. | in vitro | waltonitone (10 μM, 25 μM; for 48 hours) results in an increment of sub-G1 population in BEL-7402 cells. Waltonitone (25 μM; for 48 hours) induces BEL-7402 apoptosis cells. Waltonitone (25 μM; for 48 hours) can effectively activate caspase-3 in BEL-7402 cells. | in vivo | Waltonitone (iv; 20 mg/kg or 50 mg/kg; once every two days for 16 days) inhibits BEL-7402 tumor growth in male athymic mice (BALB/c nu/nu) in vivo. < br/> |
| waltonitone Preparation Products And Raw materials |
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