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| | Pristinamycin IA Basic information |
| Product Name: | Pristinamycin IA | | Synonyms: | N-[(3-Hydroxy-2-pyridinyl)carbonyl]-L-threonyl-(2R)-2-aMinobutanoyl-L-prolyl-4-(diMethylaMino)-N-Methyl-L-phenylalanyl-(2S)-4-oxo-2-piperidinecarbonyl-(2S)-2-phenylglycine (6-13)-lactone;NSC 92554;PA 114B;PristinaMycin P 1;Ostreogrycin B, PristinaMycin IA, StreptograMin B, Syncothrecin B1, Synergistin B, VernaMycin Balpha, VirginiaMycin 1A, NSC 125176, 14725-1, PA 114B, RP 12535;VirginiaMycin B;mikamycin B;N-[(3-Hydroxy-2-pyridinyl)carbonyl]cyclo(L-Thr*-D-Abu-L-Pro-N-methyl-4-(dimethylamino)-L-Phe-4-oxo-L-2-piperidinecarbonyl-L-phenyl Gly-) | | CAS: | 3131-03-1 | | MF: | C45H54N8O10 | | MW: | 866.96 | | EINECS: | | | Product Categories: | Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals | | Mol File: | 3131-03-1.mol |  |
| | Pristinamycin IA Chemical Properties |
| Melting point | 198° | | alpha | D22 -57.5° (c = 0.25 in ethanol) | | Boiling point | 780.3°C (rough estimate) | | density | 1.1881 (rough estimate) | | refractive index | 1.6910 (estimate) | | storage temp. | -20°C Freezer | | solubility | DMSO (Slightly), Methanol (Slightly) | | form | Solid | | pka | pKa 7.20±0.05(H2O,t =25,I=0.2(LiClO4)) (Uncertain) | | color | Pale Yellow |
| RIDADR | 3172 | | HazardClass | 6.1(b) | | PackingGroup | III |
| | Pristinamycin IA Usage And Synthesis |
| Uses | Virginiamycin B is a depsipeptide antibiotic co-produced with ostreogrycin A, together used as a syngergistic mixture. Virginiamycin B, also known as ostreogrycin B and streptogramin B among other synonyms, was discovered independently and named by several groups, leading to considerable confusion in the literature. Viriginiamycin B acts a syngergist, binding to the conformational change of the peptidyl transferase centre of the 50S ribosome induced by ostreogrycin A. | | Uses | One of the two major components of Pristinamycin (Pristinamycin IA and Pristinamycin IIA (or Virginiamycin M1-V673810). | | Definition | ChEBI: A cyclodepsipeptide that is (together with pristinamycin IIA) a component of pristinamycin, an oral streptogramin antibiotic produced by Streptomyces pristinaespiralis. Pristinamycin exhibits bactericidal activity against Gram positive organis
s including methicillin-resistant Staphylococcus aureus. | | Contact allergens | Pristinamycin is a systemic antibiotic of the synergistins/
streptogramins class, composed of two subunits: pristinamycin
IA and pristinamycin IIA. It induces several
types of drug reactions such as maculo-papular exanthema,
systemic dermatitis, or acute generalized exanthematous
pustulosis. Some patients have been previously
skin-sensitized by virginiamycin. Crossreactivity
is expected to virginiamycin and to the associated dalfopristin
and quinupristin. |
| | Pristinamycin IA Preparation Products And Raw materials |
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