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P-HYDROXYMETHAMPHETAMINE

P-HYDROXYMETHAMPHETAMINE Basic information
Product Name:P-HYDROXYMETHAMPHETAMINE
Synonyms:(αS)-4-Hydroxy-N,α-dimethylbenzeneethanamine;4-[(S)-2-(Methylamino)propyl]phenol;d-p-Hydroxymethamphetamine;Veritol;rac Pholedrine;4-(2-methylaminopropyl)phenol;(S)-N,α-Dimethyl-4-hydroxybenzeneethanamine;P-HYDROXYMETHAMPHETAMINE
CAS:370-14-9
MF:C10H15NO
MW:165.23
EINECS:206-725-0
Product Categories:Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:370-14-9.mol
P-HYDROXYMETHAMPHETAMINE Structure
P-HYDROXYMETHAMPHETAMINE Chemical Properties
Melting point 162-163°
Boiling point 293.09°C (rough estimate)
density 1.0203 (rough estimate)
refractive index 1.4820 (estimate)
storage temp. −20°C
solubility Methanol (Slightly)
pka9.82±0.15(Predicted)
Safety Information
Hazard Codes Xi,T,F
Risk Statements 36/37/38-39/23/24/25-23/24/25-11
Safety Statements 26-36-45-36/37-16-7
WGK Germany 3
RTECS SL8400000
ToxicityLD50 parenteral in mouse: 100mg/kg
MSDS Information
P-HYDROXYMETHAMPHETAMINE Usage And Synthesis
Chemical PropertiesOff-White Solid
OriginatorPholedrine Sulfate, ZYF Pharm Chemical
UsesAn a-adrenergic agonist. Antihypotensive.
DefinitionChEBI: Pholedrine is a member of amphetamines.
Manufacturing Process100 g β-(methoxyphenyl)isopropylamine prepared, for example by reduction of p-methoxybenzylmethylketone with hydrogen and nickel catalyst in presence of ammonia or by Mannix's method, 250 ml ethanol and calculated quantity of solution of formaldehyde and 70 g activated aluminum shaving were heated for 6 hours by stirring. The mixture was filtered, the solvent was removed in vacuum and the residue was dissolved in ethanol contained hydrochloric acid. The prepared hydrochloride of β-(pmethoxyphenyl)isopropylmethylamine had MP: 174°C.
In practice it is usually used as sulfate.
Therapeutic FunctionSympathomimetic, Mydriatic, Analeptic, Vasopressor
P-HYDROXYMETHAMPHETAMINE Preparation Products And Raw materials
Raw materialsHydrogen-->4-Methoxyphenylacetone-->Nickel
Tag:P-HYDROXYMETHAMPHETAMINE(370-14-9) Related Product Information
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