|
| P-HYDROXYMETHAMPHETAMINE Basic information |
| P-HYDROXYMETHAMPHETAMINE Chemical Properties |
Melting point | 162-163° | Boiling point | 293.09°C (rough estimate) | density | 1.0203 (rough estimate) | refractive index | 1.4820 (estimate) | storage temp. | −20°C | solubility | Methanol (Slightly) | pka | 9.82±0.15(Predicted) |
| P-HYDROXYMETHAMPHETAMINE Usage And Synthesis |
Chemical Properties | Off-White Solid | Originator | Pholedrine Sulfate, ZYF Pharm Chemical | Uses | An a-adrenergic agonist. Antihypotensive. | Definition | ChEBI: Pholedrine is a member of amphetamines. | Manufacturing Process | 100 g β-(methoxyphenyl)isopropylamine prepared, for example by reduction of p-methoxybenzylmethylketone with hydrogen and nickel catalyst in presence of ammonia or by Mannix's method, 250 ml ethanol and calculated quantity of solution of formaldehyde and 70 g activated aluminum shaving were heated for 6 hours by stirring. The mixture was filtered, the solvent was removed in vacuum and the residue was dissolved in ethanol contained hydrochloric acid. The prepared hydrochloride of β-(pmethoxyphenyl)isopropylmethylamine had MP: 174°C. In practice it is usually used as sulfate. | Therapeutic Function | Sympathomimetic, Mydriatic, Analeptic, Vasopressor |
| P-HYDROXYMETHAMPHETAMINE Preparation Products And Raw materials |
|