| Company Name: |
Shanghai Universal Biotech Co.,Ltd
|
| Tel: |
18768175414 |
| Email: |
gaojun@univ-bio.com |
| Products Intro: |
Product Name:5-Lipoxygenase Polyclonal Antibody
Package:1ea Remarks: 见优宁维官网
|
| Company Name: |
Cayman Chemical Company
|
| Tel: |
(800) 364-9897 |
| Email: |
cayman@caymanchem.com |
| Products Intro: |
Product Name:5-Lipoxygenase Polyclonal Antibody
Remarks:160402
|
|
| | 5-Lipoxygenase Polyclonal Antibody Basic information |
| | 5-Lipoxygenase Polyclonal Antibody Chemical Properties |
| | 5-Lipoxygenase Polyclonal Antibody Usage And Synthesis |
| Description | 5-Lipoxygenase (5-LO) is an enzyme encoded by ALOX5 in humans that is involved in leukotriene biosynthesis. It is comprised of an N-terminal regulatory domain and a C-terminal catalytic domain and is primarily expressed in leukocytes. Increases in intracellular calcium levels or cellular stress induce translocation of 5-LO from the cytosol or nucleoplasm, depending on the cell type and 5-LO phosphorylation status, to the nuclear envelope, where it interacts with 5-LO-activating protein (FLAP), which transfers arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607) to 5-LO. 5-LO catalyzes the conversion of arachidonic acid to 5(S)-HpETE and then to leukotriene A4 (LTA4). Other substrates of 5-LO include 5,8,11,14,17-eicosapentaenoic acid, 5,8,11-eicosatrienoic acid, 5,8-eicosadienoic acid, 12-HpETE, and 15-HpETE. Alox5 knockout mice are protected against arthritis and pulmonary inflammation. Knockout of Alox5 also protects apolipoprotein E-deficient hyperlipidemic mice from high-fat diet-induced hepatic injury and inflammation. Levels of 5-LO are elevated in postmortem hippocampus and cortex of patients with Alzheimer''s disease. Cayman''s 5-Lipoxygenase Polyclonal Antibody can be used for Western blot and immunohistochemistry applications. The antibody recognizes 5-LO at 78 kDa from human and porcine samples. |
| | 5-Lipoxygenase Polyclonal Antibody Preparation Products And Raw materials |
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