- Heterophyllin B
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- $0.00 / 20mg
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2023-02-24
- CAS:145459-19-4
- Min. Order: 5mg
- Purity: ≥98%(HPLC)
- Supply Ability: 10 g
- Heterophyllin B
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- $3.00 / 1KG
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2020-01-18
- CAS:145459-19-4
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 1kg , 5kg, 50kg
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| | Heterophyllin B Basic information |
| Product Name: | Heterophyllin B | | Synonyms: | Heterophyllin B;Heterophylin B;Prince Ginseng Cyclic Peptide B;Cyclo(glycylglycyl-L-isoleucyl-L-prolyl-L-prolyl-L-prolyl-L-isole ucyl-L-phenylalanyl);Cyclo(glycylglycyl-L-leucyl-L-prolyl-L-prolyl-L-prolyl-L-isoleucyl-L-phenylalanyl);(6S,15S,18S,20aS,25aS,30aS)-15-Benzyl-18-((S)-sec-butyl)-6-isobutylicosahydro-1H,25H-tripyrrolo[1,2-a:1',2'-d:1'',2''-g][1,4,7,10,13,16,19,22]octaazacyclotetracosin-5,8,11,14,17,20,25,30(30aH)-octaone;(6S,15S,18S,20aS,25aS,30aS)-15-Benzyl-18-((S)-sec-butyl)-6-isobutylicosahydro-1H,25H-tripyrrolo[1,2-a:1',2'-d:1'',2''-g][1,4,7,10,13,16,19,22]octaazacyclotetracosin-5,8,11,14,17,20,25,30(30aH)-octaone | | CAS: | 145459-19-4 | | MF: | C40H58N8O8 | | MW: | 778.94 | | EINECS: | 300-006-6 | | Product Categories: | reagent;standard substance | | Mol File: | 145459-19-4.mol |  |
| | Heterophyllin B Chemical Properties |
| Boiling point | 1159.7±65.0 °C(Predicted) | | density | 1.29±0.1 g/cm3 (20 ºC 760 Torr) | | storage temp. | 4°C, protect from light | | solubility | Soluble in DMSO | | pka | 13.44±0.70(Predicted) |
| | Heterophyllin B Usage And Synthesis |
| Chemical Properties | White crystal, easily soluble in methanol, derived from Radix Radix. | | Uses | Taizishencyclopeptide B has the functions of invigorating qi and blood, invigorating body fluid and invigorating the spleen and stomach. And it was used for content determination/identification/pharmacological experiments, etc. | | Biological Activity | Heterophyllin B is an active cyclic peptide isolated from Pseudostellaria heterophylla. It can be used in esophageal cancer research. | | in vitro | Heterophyllin B (0-200 μM; 12-48 hours) reduces cell viability in the 75, 100 and 200 μM groups, has no effect on 5, 10, 25 and 50 μM groups.Heterophyllin B (0 -50 μM; 6 hours) suppresses the expression levels of p-PI3K, p-AKT and β-catenin in a dose-dependent manner in ECA-109 cells. < /p> Cell Viability Assay | Cell Line: | ECA-109 cells | | Concentration: | 5 μM, 10 μM, 25 μM, 50 μM, 75 μM, 100 μM and 200 μM | | Incubation Time: | 12, 24 and 48 hours | | Result: | Decrease cell viability at high concentrations. | Western Blot Analysis | Cell Line: | ECA-109 cells | | Concentration: | 0 μM, 10 μM, 25 μM, 50 μM | | Incubation Time: | 6 hours | | Result: | Decreased the phosphorylation of PI3K/AKT and the expression of β-catenin. | |
| | Heterophyllin B Preparation Products And Raw materials |
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